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Retinoids in Keratinization Disorders
Published in Ayse Serap Karadag, Berna Aksoy, Lawrence Charles Parish, Retinoids in Dermatology, 2019
Knuckle pads can be sporadic and rarely familial. Trauma is not an etiologic factor. The condition is characterized by keratotic and fibrotic lesions on the dorsal aspect of the fingers after the late-childhood period. Dupuytren contracture can occur rarely. Treatment is unsatisfactory, but surgery, topical steroids, salicylic acid gel, retinoids, carbon dioxide freezing, intralesional steroid, and 5-fluorouracil injections are recommended (82,83).
Benign tumors
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Knuckle pads occur mainly on the dorsal surface of the metacarpophalangeal and interphalangeal joints and may extend to the proximal nail fold. They are persistent, asymptomatic, slightly hyperpigmented, keratotic plaques more often seen in men. They are probably due to chronic rubbing and other chronic repeated traumas.108 Similar lesions on the finger joints and clubbing of the nails were associated with epidermolytic palmar and plantar keratoderma of Vörner.109 Pseudo-knuckle pads, called chewing pads110 or pachydermodactyly,111 may be a sign of obsessive-destructive behavior.112
Fibrous tumors
Published in Eckart Haneke, Histopathology of the NailOnychopathology, 2017
Knuckle pads are persistent asymptomatic, slightly hyperpigmented, keratotic plaques mainly occurring on the dorsal surface of the metacarpophalangeal and interphalangeal joints, sometimes extending to the proximal nail fold. Men are predominantly affected. They are most probably a reaction to chronic rubbing and other chronic repeated traumas.18 Knuckle pad-like keratoses on the finger joints and clubbing of the nails may be associated with epidermolytic palmar and plantar keratoderma of Vörner.19 Pseudo-knuckle pads, also called chewing pads20 or pachydermodactyly,21 may be a sign of obsessive-destructive behavior.22
Assessment of various intralesional injections in keloid: comparative analysis
Published in Journal of Dermatological Treatment, 2022
Waleed Albalat, Sara Nabil, Fathia Khattab
It has been documented for its efficacy and safety in treating other fibroid conditions, counting infantile digital fibromatosis, knuckle pad, rheumatoid nodules, and adverse foreign body reactions and sarcoid granuloma complication following injection of soft tissue filler when employed as mono-therapy or combined with additional medicinal products (e.g. TAC). Some statistics propose that 5-FU is operative for treating hypertrophic scar and that it is very useful for minor keloid.
An ultrastructural pathologist’s views on fibroblasts, modified smooth muscle cells, wound healing, stenosing arteriopathies, Kawasaki disease, Dupuytren’s contracture, and the stroma of carcinomas
Published in Ultrastructural Pathology, 2020
TEM will be required to decipher the cellular components of the different phases of superficial and musculoaponeurotic fibromatoses, which include palmar, plantar, and penile fibromatosis and knuckle pads. Likewise, it is needed to ascertain the roles of fibroblasts and mSMCs in desmoid tumors, infantile fibromatosis, and desmoplastic fibroma of bone, as well as a long list of soft tissue proliferations, such as nodular and proliferative fasciitis.