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Arteropathies, Microcirculation and Vasculitis
Published in Mary N. Sheppard, Practical Cardiovascular Pathology, 2022
Intravascular papillary endothelial hyperplasia (IPEH) is an unusual form of proliferating endothelium in the setting of organizing thrombus. Although benign, this lesion is clinically important, because it presents as a mass lesion, may be confused histologically with angiosarcoma, and tends to recur if incompletely resected. Historically, IPEH has been described as occurring in numerous locations throughout the body. It can be associated with aneurysms. The wall can be markedly thickened by nodular cellular tissue containing both large and small vascular channels. More cellular areas consisted of numerous capillary-sized vascular channels resembling granulation tissue in a cellular matrix containing myxoid collagenous tissue, fresh and degenerating blood, clusters of hemosiderin-laden macrophages, and scattered mononuclear inflammatory cells. Unlike organizing thrombi, which typically regress with time, IPEH exhibits tumour-like growth and recurs when incompletely resected. Histological comparisons with organizing thrombi suggest that IPEH is a form of abnormal organization from thrombus formation. IPEH can mimic vascular neoplasms such as angiosarcoma. Unlike angiosarcoma, which virtually never occurs within the lumen of a vessel, IPEH typically arises within and remains confined to the lumen of a vessel or aneurysm. Common locations include the fingers, scalp, neck and trunk, where the lesions appear as red or blue, firm, small, superficial masses. Multiple lesions may represent examples of IPEH occurring in the setting of a systemic angiomatosis syndrome.
Vascular tumors
Published in Eckart Haneke, Histopathology of the NailOnychopathology, 2017
Usually, intravascular papillary endothelial hyperplasia is situated within an ectatic thin-walled vein that is often partially thrombotic. Parts of the thrombus may be in organization. The lumen contains villous proliferations of endothelia with an inconspicuous connective tissue core. Mitoses and cellular atypias are absent (Figure 10.1).
Apoplexy of a collision tumour composed of subependymoma and cavernous-like malformation in the lateral ventricle: a case report
Published in British Journal of Neurosurgery, 2019
Motaz Alsereihi, Fatima Turkistani, Fahad Alghamdi, Saleh Baeesa
In our case, there was a distinct demarcation between the subependymoma and the vascular lesion with haemorrhage. The vascular lesion may represent a de novo cavernous malformation with secondary haemorrhage; supported by the presence of a collection of many back-to-back dilated vascular channels having thin walls that contain no brain tissue in between. Other differential diagnosis includes intravascular papillary endothelial hyperplasia (Masson's tumour) that characterizes typically by papillary proliferation of fibrous or hyaline stalks covered by endothelial cells and anastomosing vascular spaces on back ground of thrombus. Masson’s tumor arises usually within a normal blood vessel (often a vein). Occasionally, it arises within a preexisting vascular malformation (like a cavernous malformation) or an organizing haematoma. Our case could be one of the those occasional cases that arise within a haematoma, however, the characteristic vascular papillary projections of Masson’s tumor were not seen; and therefore Masson’s tumor is probably not the favorable diagnosis for our case.
Intravascular papillary endothelial hyperplasia of the finger: a case of Masson’s tumor
Published in Case Reports in Plastic Surgery and Hand Surgery, 2021
Kun-Yong Sung, Seungkoo Lee, Yeonjin Jeong, Sang-Yeul Lee
Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson’s tumor, is an uncommon benign vascular lesion characterized by a reactive proliferation of endothelial cells. The lesion arising from an ulcerated hemorrhoidal vein was first described by Masson [1] as a ‘vegetant intravascular hemangioendothelioma’. Thereafter, it has been reported with diverse descriptions such as intravascular angiomatosis, intravenous vascular proliferation, Masson’s pseudoangiosarcoma, and Masson’s tumor. Masson believed that it was a specific type of hemangioma. However, Henschen [2] proposed that the endothelial proliferation is reactive rather than neoplastic. The descriptive term ‘intravascular papillary endothelial hyperplasia’ was first proposed by Clerkin and Enzinger [3].
Papillary Endothelial Hyperplasia of Scalp with Bone Erosion: A Case Report with Review of Literature
Published in Fetal and Pediatric Pathology, 2021
Divya Shetty, Ritika Khurana, Sudhamani S., Sneha Padmakar, Rajiv Rao
PEH was first described by Pierre Masson in 1923 in an ulcerated hemorrhoidal vein and he designated it as vegetant intravascular hemangioendothelioma [1,2]. In 1929, Folke Henschen re-described it as a reactive response to inflammation and stasis in blood vessels and re-named it endovasculite proliférante thrombopoïétique [1]. Since then the lesion has been described by various names in the literature, including intravascular angiomatosis, Masson’s pseudoangiosarcoma, Masson’s hemangioma and Masson’s vegetant intravascular hemangioendothelioma. Later, in 1976, the lesion was named intravascular papillary endothelial hyperplasia by Kevin Clearkin and Dr. Franz Enzinger, which is being used today [6].