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Polymorphous Light Eruption, Hydroa Vacciniforme, and Actinic Prurigo
Published in Henry W. Lim, Herbert Hönigsmann, John L. M. Hawk, Photodermatology, 2007
Herbert Hönigsmann, Maria Teresa Hojyo-Tomoka
Hydroa vacciniforme (HV) is a very rare photodermatosis of unknown etiology that principally starts in childhood, frequently resolving by adolescence or young adulthood. It is characterized by recurrent crops of papulovesicles or vesicles most commonly on the face and the dorsa of the hands, but other sun-exposed areas of the skin may also be involved. The vesicles resolve with pocklike scarring. The disease was first described by Bazin (52) in 1862, and it is possible that before the clear definition of erythropoietic protoporphyria by Magnus et al. (53), some cases may have been protoporphyria rather than hydroa because of the similarity of symptoms. Some recent reports of an association with Epstein–Barr virus (EBV) infection are interesting (54–56), but not all of the described cases are typical, associated with lymphoma (57) and may well be a different entity; but this is up to further investigations.
Ocular Involvement Preceded the Onset of Cutaneous Lesions in Hydroa Vacciniforme-Like Lymphoproliferative Disorder: A Case Report
Published in Ocular Immunology and Inflammation, 2022
Renpan Zeng, Lixia Du, Danling Wang
Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a rare Epstein–Barr virus (EBV) associated lymphoproliferative photodermatosis, which affects mostly children, occurring more frequently in Asians and Latin Americans with risk of progression to lymphoma.1 It was initially designated under the 2008 WHO classification of tumors of hematopoietic and lymphoid tissues as a distinct entity. Recently, it has been reclassified as a lymphoproliferative disorder in the new 2016 revision of the WHO classification of lymphoid neoplasms.2 Patients display with recurrent erythema and papulovesicles symmetrically distributed over the sun-exposed skin, which evolving to necrotic-crusted ulcers and healing with vacciniform or varioliform scars.
Recent advances in the diagnosis and treatment of natural killer/T-cell lymphomas
Published in Expert Review of Hematology, 2019
Eric Tse, Rex Au-Yeung, Yok-Lam Kwong
NK/T-cell lymphomas are predominantly de novo malignancies. However, in exceptional cases, a pre-existing lesion may be found. Hydroa vacciniforme-like lymphoma is an EBV-positive chronic cutaneous lymphoproliferative disease occurring mostly in South American and sometimes in Asian children. Prognosis is favorable, but rare cases may develop into an NK/T-cell lymphoma [3,8]. Chronic active EBV infection is a very unusual condition characterized by a persistent febrile illness associated with high titers of anti-EBV antibodies, lymphadenopathy, impaired liver function and variable degrees of cytopenia [3,8]. Although evolution into a T-cell lymphoma is more common, progression to an NK/T-cell lymphomas may occur.