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Transfollicular elimination of sebaceous glands in a patient with disseminate and recurrent infundibulofolliculitis
Published in Baylor University Medical Center Proceedings, 2021
Mahmud Alkul, Travis S. Dowdle, Jay Truitt, Michelle B. Tarbox
Differential diagnoses for DRIF include bacterial and fungal folliculitis, follicular eczema, keratosis pilaris, and truncal acne, among others.3 Although rare Pityrosporum yeast were demonstrated on biopsy, their presence in only some of the follicles make this diagnosis less likely. Follicular eczema is characterized by inflammatory infiltrate not limited to the infundibulum of the hair follicle.2 Keratosis pilaris is clinically significant for hyperkeratinization.2 Lesions may be differentiated from truncal acne vulgaris by histopathology revealing follicular dilation, increased sebum production, and accumulation of keratin.4 DRIF has been associated with other dermatologic conditions such as hidradenitis suppurativa, a chronic inflammatory disease of the pilosebaceous unit, especially in patients with trisomy 21.5