China
Africa
Explore chapters and articles related to this topic
American Dermatology in the Nineteenth Century
Published in Scott M. Jackson, Skin Disease and the History of Dermatology, 2023
After his first publication, Fox's professional career skyrocketed, and he was offered professorships in dermatology; he settled into that role at the College of Physicians and Surgeons (now Columbia University) in 1880, where he remained for 26 years. In addition to his groundbreaking photographic atlases, Fox contributed to the corpus of dermatologic knowledge by describing in 1902 the underarm rash of young women known today as Fox-Fordyce disease, along with his colleague John Addison Fordyce (1858–1925). He was also one of several figures to describe matchbox dermatitis, a particularly itchy, obsolete rash caused by contact with the material composing the striking surface of matchboxes.
Tretinoin
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
A small case series of 3 patients (no details on sex and age) with allergic contact dermatitis from tretinoin was reported in 1976 (13). The patients were treated with tretinoin 0.05% cream, two for hereditary keratoderma and one for Fox-Fordyce disease. Patient 1 developed fairly acute itching and erythema on the treated areas after 14 weeks. Patient 2 showed acute vesicular eczema on the hands, feet, inside of the thighs, and face after seven weeks’ treatment. The patient with Fox-Fordyce disease developed itching and erythema of the treated axilla after only one week. Patch tests were positive to the 0.05% cream, 2/2 to another brand 0.05% cream, and to tretinoin 0.05% and 0.005% in alc. 96%. One also reacted to the cream base from allergy to stearyl alcohol. The 0.05% preparations caused irritant reactions in controls. The weaker alcoholic solution (0.005%) caused no primary reactions. In three out of 10 controls, however, erythema developed after 5-6 days at the site of the test; in two of these, papules appeared, and in one there was also itching (13). Patient 3 may have had irritant contact dermatitis and false-positive patch tests.
Skin diseases of the vulva: inflammatory, erosive-ulcerating and apocrine gland diseases, zinc and vitamin deficiency, vulvodynia and vestibulodynia
Published in Journal of Obstetrics and Gynaecology, 2018
Freja Lærke Sand, Simon Francis Thomsen
The aetiology of Fox–Fordyce disease is unknown, but the current view is that it results from apocrine sweat retention caused by plugging of the follicular infundibulum and subsequent rupture of the adjacent intraepithelial portion of the apocrine duct (Shelley and Levy 1956). Women with Fox–Fordyce disease therefore have complete apocrine anhidrosis, whereas eccrine sweating is normal. The disease mainly affects the axillary and pubic regions. Fox–Fordyce disease begins shortly after puberty and usually runs a protracted course but rarely persists after menopause. Symptoms are intense itch in affected areas and the clinical signs are formation of skin-coloured or slightly pigmented dome-shaped follicular papules in the pubic area. Emotional stress may cause bouts of itching. Chronic itching and scratching may result in lichenification and hair loss. The diagnosis is based primarily on clinical presentation, but histopathology may confirm the diagnosis (Stashower et al. 2000). Response to therapy is often unsatisfactory. Several treatment modalities have been tried including topical clindamycin, corticosteroids and pimecrolimus (applied twice daily for eight weeks) as well as systemic retinoids and oral contraceptives (Pock et al. 2006). Electrocautery, CO2-laser, botulinum toxin injection and surgical excision are alternative options.
Fox Fordyce disease: a side effect of laser therapy
Published in Journal of Cosmetic and Laser Therapy, 2020
Histopathological examination reported slight parakeratotic hyperkeratosis with dense perifollicular and periductal inflammatory infiltration of histiocytes and lymphocytes in the mid dermis. Dilatation of follicular ostium, and follicular plugging were also observed (Figure 2). “Fox-Fordyce” disease was diagnosed on the basis of clinical and histopathological findings. Topical 0.1% tacrolimus gel was initiated as treatment.