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Nigella sativa Encapsulated Nano-Scaffolds and Their Bioactivity Significance
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mohammed Asadullah Jahangir, Abdul Muheem, Syed Sarim Imam, Farhan Jalees Ahmed, Mohd. Aqil
N. sativa and its extract act against Candida albicans and Madurella mycetomatis. The activity of the extracts of N. sativa was claimed to be potentially more effective than antibiotics like amphotericin-B and griseofulvin against Aspergillus niger, Fusarium solani, and Scopulariopsis brevicaulis. Moreover, TQ confirmed potential activity against Trichophyton spp., Epidermophyton spp., and Microsporum spp. Aqueous extracts of N sativa showed no antifungal activity. The plant extract of N. sativa caused a significant inhibition of the growth of the fungi, Candida albicans (Aljabre et al., 2015). Size reduction of Amphotericin-B, Ketoconazole, and Thymoquinone was attempted by the ball milling technique, and particle size was found to be 5 to 20 nm. The nanoparticulated drug and the conventionally available microstructured drug form were examined against Candida albicans yeast and candida biofilm. Prepared nanosized drug particles were found to be two or four times effective in both candida yeasts and candida biofilm (Randhawa et al., 2015).
Skin infections
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
Shankila Mittal, Rashmi Sarkar
The species causing dermatophytic infection can be classified as:Anthropophilic – e.g., Epidermophyton floccosum, Trichophyton mentagrophytes var. Interdigitale, Trichophyton rubrum, Trichophyton schoenleinii, Trichophyton soudanense, Trichophyton tonsurans, Trichophyton violaceum, etc.Zoophilic – Microsporum canis (dogs, cats), T. verrucosum (cattle) and T. equinum (horses).Geophilic – Microsporum gypseum, Microsporum praecox
In-Vitro Antidermatophytic Bioactivity of Peel Extracts of Red Banana (Musa Acuminate) and Common Banana (Musa Paradisica)
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Shivakumar Singh Policepatel, Pavankumar Pindi, Vidyasagar Gunagambhere Manikrao
Investigators and healers of conventional medicines have documented health benefits of therapeutic plants to treat dermatological diseases. The ring worm is known as dermatophytes. The three main genera—Microsporum, Trichophyton, and Epidermophyton—are strongly allied plant—scientifically. Among these, Microsporum is a recurrent reason for ring worm of scalp and might furnish augment to ring worm in all parts of the carcass. While Trichophyton cause ringworm from the scalp as well as erstwhile areas of crust and nails. Epidermophyton is mainly accountable to ringworm affecting surface of the skin, hands, and feet; and has been found to interlace within the skin, and it does not assault tresses.15Candida species establishes in the gastro-intestinal tract, oral cavity, and vagina.3
Miconazole for the treatment of vulvovaginal candidiasis. In vitro, in vivo and clinical results. Review of the literature
Published in Journal of Obstetrics and Gynaecology, 2023
Pedro Antonio Regidor, Manopchai Thamkhantho, Chenchit Chayachinda, Santiago Palacios
Millions of patients have been treated with this compound in various formulations. Common indications for topical miconazole include vaginal and oral candidiasis, skin and nail infections due to Trichophyton, Epidermophyton, and Pityrosporon species, dermatomycosis, and onychomycosis (Zhang et al.2019, Saxon et al.2020, Kaur et al.2021, Workowski et al.2021). Miconazole antifungals are available most commonly in cream but also in gel, solution or spray formulations at a 1% (Jartarkar et al.2021) or 2% concentration (Ridzuan et al.2019), and most are indicated for use twice-daily for 2–4 weeks (Jartarkar et al.2021) or occasionally for up to 6 weeks if required (Barasch and Griffin 2008). More potent miconazole-containing topical preparations are also used, such as in the USA, where several products that contain miconazole, typically a 2–4% cream, have been approved for over the counter (OTC) sale (Hay 2018). When using miconazole topically, particularly in the form of a cream, serious adverse effects are uncommon; reports of maceration, redness of the skin, and allergic or irritant contact dermatitis are sporadic and rare (Poojary 2017).
The antifungal pipeline for invasive fungal diseases: what does the future hold?
Published in Expert Review of Anti-infective Therapy, 2023
Chin Fen Neoh, Wirawan Jeong, David CM Kong, Monica A Slavin
Olorofim has potent in vitro activity against Coccidioides immitis and C. posadasii (Figure 2) and was shown to be efficacious in murine model of cerebral coccidioidomycosis infected by C. immitis [89]. It also exhibited good in vitro activity against other fungi including Rasamsonia argillacea species complex, Metarrhizium anisopliae, Pleurostomophora richardsiae, Talaromyces marneffei, Sarocladium kiliense, Penicillium spp., Scopulariopsis spp., Ramularia spp., Epidermophyton floccosum, Trichophyton spp., Microsporum spp. and Madurella mycetomatis, but has marginal activity against Phialemonium curvatum and Phaeoacremonium parasiticum [64,73,84,90–96].
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea
Published in Drug Delivery, 2021
Adel F. Alghaith, Sultan Alshehri, Nabil A. Alhakamy, Khaled M. Hosny
Superficial fungal infections, such as tinea, are one of the most prevailing infections worldwide primarily caused by dermatophytes of the genera Epidermophyton, Microsporum, and Trichophyton (Branscomb, 2005). Such aerobic pathogenic fungi can grow and colonize on keratinized tissues like skin, hair and nails, owing to their ability to produce numerous proteolytic enzymes that can digest keratin (Branscomb, 2005). These infected keratinized tissues provide the desired temperature, pH, and nitrogen conditions to meet the nutritional needs of dermatophytes; therefore, such infections are restricted to superficial cutaneous tissues and rarely extend to deeper subcutaneous ones (Bottone, 2006). Although several antifungals have been reported to have essential activity against dermatophytes, such infections often relapsed after the medication was stopped since these organisms established a tolerance to prolonged treatment (Mukherjee et al., 2003).