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Paper 4
Published in Amanda Rabone, Benedict Thomson, Nicky Dineen, Vincent Helyar, Aidan Shaw, The Final FRCR, 2020
Amanda Rabone, Benedict Thomson, Nicky Dineen, Vincent Helyar, Aidan Shaw
The features described are typical of a giant cell tumour, which is an eccentric lesion occurring in a fused skeleton, abutting the articular surface with a well-defined non-sclerotic margin. Aneurysmal bone cysts are lucent lesions occurring in the metaphysis with thinning of the cortex and fine internal trabeculation; however, they usually occur in patients less than 30 years old. Eosinophilic granuloma also occurs in patients less than 30 years old. Fibrous dysplasia can look like anything. It typically has a sclerotic rim. Non-ossifying fibromas are rarely seen in patients over 30 years old. They usually have a thin sclerotic border.
The cases
Published in Chris Schelvan, Annabel Copeman, Jacky Davis, Annmarie Jeanes, Jane Young, Paediatric Radiology for MRCPCH and FRCR, 2020
Chris Schelvan, Annabel Copeman, Jacky Davis, Annmarie Jeanes, Jane Young
Overlap occurs in the radiological appearances of Ewing’s sarcoma and osteosarcoma. Infection and eosinophilic granuloma can occasionally give similar appearances on the plain film and a bone biopsy is required in all cases to establish histology.
Pulmonary Involvement in Systemic Cancer
Published in Lourdes R. Laraya-Cuasay, Walter T. Hughes, Interstitial Lung Diseases in Children, 2019
Michael R. Bye, Daniel V. Schidlow
A less severe form of the disease, Hand-Schuller-Christian Disease typically affects slightly older children than does Letterer-Siwe. The common manifestations of Hand-Schuller-Christian Disease are in the bones but there may be a concomitant diabetes insipidus. Pulmonary involvement may be diffuse or occur as nodular invasions by Langerhans cells. Eosinophilic granuloma is the most localized and benign form of the disease. Involvement may be unifocal, or multifocal but limited to one organ or organ system. Most often the lesions are in the bones. A pulmonary syndrome may fit in this category, with the lung being the sole organ involved.23 Pathologic findings in the lung may include alveolar filling by histiocytes and eosinophils; interstitial infiltration by the cells occasionally with formation of nodules 2 to 4 mm; or an endarteritis may lead to interstitial fibrosis with honeycomb lung or spontaneous pneumothorax.25,26
Imaging features of hepatobiliary MRI and the risk of hepatocellular carcinoma development
Published in Scandinavian Journal of Gastroenterology, 2022
Jong-In Chang, Dong Hyun Sinn, Woo Kyoung Jeong, Jeong Ah Hwang, Ho Young Won, Kyunga Kim, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung-Woon Paik
Some high-risk nodules were stationary or even downgraded from LR-4 to LR-3. Supplementary Figure 2 demonstrated that a case of the observation was downgraded from LR-4 to LR-3 in a short-term period. The baseline hepatobiliary MRI of a 48-year-old male patient with chronic liver disease of non-alcoholic steatohepatitis showed a 0.9 cm nodule with faint nonrim APHE. This lesion showed washout in the portal venous phase and hypointensity in the HBP and even had restricted diffusion on the diffusion weighted image. Since the lesion was less than 1 cm in size, it was categorized as an LR-4 lesion. The follow-up MRI was done two months later and the lesion disappeared in the arterial phase and remained only as focal hypointensity in the HBP. We assumed that this lesion could be an eosinophilic granuloma because the initial serum eosinophil count of the patients was increased to 12.2%.
Patients with suspected benign tumors and glial fibrillary acidic protein autoantibody: an analysis of five cases
Published in International Journal of Neuroscience, 2019
Qingmei Huang, Huacai Yang, Tianni Liu, Huiming Xu, Baikeng Chen, Si Liu, Wenfeng Li, Youming Long, Cong Gao
Five patients with positive GFAP antibodies in the CSF had tumors that were either past or current (three after the neurological symptom onset and two before). Detailed data from the five patients are described in Table 1. One patient was male and four were female. Their median age at onset was 54 years (range: 27–70 years) and the median disease duration was 14 months (range: 1–27 months). One patient suffered a thyroid nodule, one patient had a small nodule in the left lung, two patients suffered meningiomas and one patient had a suspicious eosinophilic granuloma (Figures 1(a) and 2(a,b,d,e)). No patients showed a worsening of disease. Typical GFAP astrocytopathy manifestations were present in all patients, including headache, fever, psychiatric or behavioral abnormalities, abnormal vision, and limb dysfunction. In addition, two patients had seizures and one patient entered a coma.
Two cases of refractory eosinophilic granulomatosis with polyangiitis wherein mepolizumab was effective against pulmonary and ear lesions
Published in Modern Rheumatology Case Reports, 2021
Yusuke Ushio, Risa Wakiya, Mikiya Kato, Tomohiro Kameda, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Koichi Sugihara, Takenori Miyashita, Norimitsu Kadowaki, Hiroaki Dobashi
Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). It is characterised by allergic rhinitis, asthmatic complications, hypereosinophilia and vasculitis. Microangiitis with eosinophilic granuloma in EGPA affects several organs, including nasal and/or throat mucosa and peripheral nerve [1].