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Malignant tumors
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
This rare neoplasm has been described under various terms, such as clear-cell papillary carcinoma, clear-cell hidradenocarcinoma, malignant clear-cell hidradenoma, malignant clear-cell acrospiroma, malignant eccrine acrospiroma, nodular hidradenocarcinoma, clear-cell eccrine carcinoma, mucoepidermoid hidradenocarcinoma, and malignant nodular clear-cell hidradenoma;2 whether the term primary mucoepidermoid carcinoma of the skin is justified remains disputed. Most patients are around 50 years of age. A slight female preponderance was noted. There is no characteristic appearance allowing a clinical diagnosis to be made. It is a slow-growing, asymptomatic solitary tumor. Two cases were described in the nail apparatus. One was that of 77-year-old black man with a slowly growing mass on the right middle fingernail bed, which began as a pigmented band rapidly enlarging in size in the last months prior to consultation. Clinically, it presented as an ulcerated dome-shaped red nodule involving most of the nail bed. The nail plate was destroyed and partially lost. The remaining nail plate on both sides of the lesion was hyperpigmented.86 Another hidradenocarcinoma of the nail apparatus appeared clinically as a recurrent onychomycosis in a 72-year-old man.
Epithelial and fibroepithelial tumors
Published in Eckart Haneke, Histopathology of the NailOnychopathology, 2017
Hidradenocarcinoma is a rare neoplasm that has been described under various terms, such as clear-cell papillary carcinoma,329 clear-cell hidradenocarcinoma,330,331 malignant clear-cell hidradenoma,332,333 malignant clear-cell acrospiroma,334 malignant eccrine acrospiroma,335 nodular hidradenocarcinoma, clear-cell eccrine carcinoma,336 mucoepidermoid hidradenocarcinoma,337 and malignant nodular clear-cell hidradenoma;338 whether the term primary mucoepidermoid carcinoma of the skin339,340 is justified remains disputed. Most patients are around 50 years of age. There may be a slight female preponderance. There is no characteristic appearance allowing a clinical diagnosis to be made. It is a slow growing, asymptomatic solitary tumor. Two cases were described in the nail apparatus. One was that of a 77-year-old black man with a slowly growing mass on the right middle finger nail bed, which had begun as a pigmented band rapidly enlarging in size in the last months prior to consultation. Clinically, there was an ulcerated dome-shaped red nodule involving most of the nail proximally to the proximal nail fold. The nail plate was destroyed and partially lost. The remaining nail plate on both sides of the lesion was hyperpigmented.341 Another hidradenocarcinoma of the nail apparatus appeared clinically as a recurrent onychomycosis in a 72-year-old man.
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors
Published in International Journal of Hyperthermia, 2018
Peter Vaupel, Helmut Piazena, Werner Müller, Markus Notter
Due to its special features in the treatment of superficial tumors with depth extensions ≤20 mm, options for wIRA-HT may include malignant melanoma (recurrences, in-transit metastases), vulvar carcinoma, skin metastases of different primary tumors, cutaneous T- and B-lymphoma, cutaneous large-area hemangiomatosis, inoperable squamous cell, basal cell and eccrine carcinoma. Photodynamic therapy using wIRA (e.g., in the treatment of precancerous actinic keratosis) is a further promising option in clinical oncology. wIRA may also be considered as a tool to combine HT with radio-, chemo- and immune-therapy of accessible mucosal malignancies using flexible light guides.