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Vulvar Disorders
Published in S Paige Hertweck, Maggie L Dwiggins, Clinical Protocols in Pediatric and Adolescent Gynecology, 2022
Tina Ho, Kaiane Habeshian, Kelsey Flood, Sameen Nooruddin, Laura Hollenbach, Kathryn Stambough, Kalyani Marathe
Fixed drug eruptionDetailed medication historyAvoid causative agent
Drug Allergy
Published in Pudupakkam K Vedanthan, Harold S Nelson, Shripad N Agashe, PA Mahesh, Rohit Katial, Textbook of Allergy for the Clinician, 2021
Fixed drug eruptions are called that because they recur in the same location on reintroduction of the causative drug. Typical fixed drug eruptions present as round or oval, sharply demarcated, red to livid, slightly elevated plaques, ranging from a few millimeters to several centimeters in diameter. They frequently involve the lips, hands and genitalia. A number of medications are associated with fixed drug eruptions including tetracycline, NSAIDs and carbamazepine (Ben Fadhel et al. 2019).
Patch Testing in Systemic Drug Eruptions
Published in Kirsti Kauppinen, Kristiina Alanko, Matti Hannuksela, Howard Maibach, Skin Reactions to Drugs, 2020
Derk P. Bruynzeel, Howard I. Maibach
Is the skin a representative test organ in drug eruptions? A drug eruption is any adverse skin reaction caused by a drug used in normal doses. The incidence of these reactions is imprecisely documented. The available figures must be interpreted carefully as the methodology of the different studies differs and there is under reporting. Approximately 2 to 5% of the patients experience an adverse skin reaction, indicating that we must see these reactions frequently in our consultations in the hospital.1 Information on outpatients is less reliable.
Disseminated herpes zoster in an immunocompetent young adult: A rare complication of Ramsay Hunt syndrome
Published in Acta Oto-Laryngologica Case Reports, 2023
Naoyuki Matsumoto, Makiko Toma-Hirano, Takuya Yasui, Ken Ito
Drug eruption has various types, e.g. morbilliform, urticarial, etc., which are non-specific for drug classification. It sometimes needs differentiation from herpetic vesicles of VZV by the experienced dermatologist. The incidence of skin rash as an adverse effect in the phase III study of famciclovir in our country was 0.9% [14]. Therefore, drug eruption is not common, either. However, disseminated herpes zoster with Ramsay Hunt syndrome among immunocompetent subjects must be even rarer, since only 3 definite cases have been reported. The differential diagnosis of the rash is important for clinical decision-making, since the antiviral drug should be continued with quarantine in case of exacerbation of VZV infection, but be withdrawn in case of a drug side effect. Although direct immunofluorescence assay for VZV antigen or polymerase-chain-reaction (PCR) assay VZV DNA can make definite diagnosis, these are not universally available and may take time according to the facilities. In the present case, diagnosis of disseminated herpes zoster was made promptly by the dermatologist. Its course of simultaneous appearance with exacerbation of symptoms and disappearance after crusting with continued administration of the antiviral drug was typical with disseminated herpes.
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect
Published in Acta Clinica Belgica, 2019
Fatma Erden, Erol Rauf Agis, Meside Gunduzoz, Omer Hinc Yilmaz
Drug eruptions are substantially common dermatological problems and can be seen in about 2.2% of inpatients [1]. Drug reactions are often maculopapular or morbilliform, but there are different types. Rather than a laboratory study, images of lesions, drug use history, clinical status of the patient, and histopathological findings in some cases help diagnosis. One of these situations is fixed drug eruptions. Fixed drug eruptions (FDE) are characterized by recurrent, usually solitary erythematous or dark red macular, plaque or bullous lesions, all at the same site [2,3]. There are many drugs that can trigger this clinical picture. Drugs often accused include sulfonamides, dapsone, barbiturates, nonsteroidal anti-inflammatory drugs, tetracycline, and carbamazepine [4]. Among the first choices for antidotal treatment in mercury exposure, DMPS (Dimaval®) is generally a drug with a low incidence of side effects. Fixed drug eruption due to DMPS was not detected in our literature review and so we aimed to present this rare case [5].
Management of immune-related adverse events resulting from immune checkpoint blockade
Published in Expert Review of Anticancer Therapy, 2019
Barouyr Baroudjian, Dimitri Arangalage, Stefania Cuzzubbo, Baptiste Hervier, Celeste Lebbé, Gwenael Lorillon, Abdellatif Tazi, Gerard Zalcman, Mohamed Bouattour, Frédéric Lioté, Jean-François Gautier, Solenn Brosseau, Nelson Lourenco, Julie Delyon
However, grade 3 and 4 rashes are rare (2% of patients treated with monotherapy and less than 5% with the combination) [6]. Clinical examination and cutaneous biopsies are often necessary to rule out a differential diagnosis such as a drug eruption induced by another treatment or a viral rash.