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Rosacea/Acne Rosacea
Published in Charles Theisler, Adjuvant Medical Care, 2023
Mild cleansing and moisturizing regimens can be beneficial. Cleansers should be fragrance and abrasive-free with a mildly acidic to neutral pH. Recommended skin cleansers include lipid-free, nonalkaline cleansers (e.g., Cetaphil) and sensitive skin synthetic detergent bars (e.g., Dove Sensitive Skin Bar).2
Dermatitides
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Allison Perz, Tara Jennings, Robert Duffy, Warren Heymann
In addition to treatment, prevention has been shown to be an effective therapeutic strategy with recent research supporting the use of calcineurin inhibitors, such as tacrolimus ointment, to prevent flares in atopic dermatitis. Because many atopic patients are allergic to lanolin, Cetaphil® lotion or cream is the recommended lubricating agent. Occasionally, bleach or tar baths may be helpful. For more severe disease, a biologic (dupilumab, a monoclonal antibody targeting the IL-4α receptor) may be indicated. Other modalities include cyclosporine, mycophenolate mofetil, methotrexate, or phototherapy.
Topical Agents
Published in John Y. M. Koo, Ethan C. Levin, Argentina Leon, Jashin J. Wu, Alice B. Gottlieb, Moderate to Severe Psoriasis, 2014
Rosemary deShazo, Gerald G. Krueger, Kristina Callis Duffin
Emollients are commonly used and highly recommended as concomitant therapy in the treatment of psoriasis. Use of emollients usually increases comfort by relieving dryness, scaling, and pruritus. The authors recommend frequent application of a cream or ointment (such as Cetaphil, Eucerin, Aquaphor, and petrolatum).
In vitro human skin percutaneous penetration: does a second topical application effect flux of first application?
Published in Journal of Dermatological Treatment, 2022
Radiolabeled benzoic acid, [7-14C] was purchased from American Radiolabeled Chemical, Inc (St Louis, MO) with specific activity of 55 mCi/mmol and non-labeled bezoic acid (BA) from Fisher Scientific (Fair Lawn, NJ). Phosphate Buffered Saline (PBS) tablet was from VWR (Solon, OH), absolute alcohol and polyethylene glycol (PEG) obtained from Aldrich (St Louis, MO). BA was dissolved in ethanol to be 2% (w/v) solution followed by adding trace amount of [14C]-BA to a final topical dosing formulation. A PBS tablet dissolved in 100 ml of distilled water and then add PEB to be a final 6% PEG-PBS solution (pH = 7.4) for receptor fluid. Cetaphil® Moisturizing Cream was from Galderma Laboratories (L.P. Fort Worth, TX). The ingredients of the cream are water, glycerin, petrolatum, dicaprylyl ether, dimethicone, glyceryl stearate, cetyl alcohol, prunus amygdalus dulcis (sweet almond) oil, PEG-30 stearate, tocopheryl acetate, acrylates/C10-30 alkyl acrylate crosspolymer, dimethiconol, benzyl alcohol, phenoxyethanol, glyceryl acrylate/acrylic acid copolymer, propylene glycol, disodium EDTA, and sodium hydroxide.
Dermatology for the internist: optimal diagnosis and management of atopic dermatitis
Published in Annals of Medicine, 2021
Shanthi Narla, Jonathan I. Silverberg
Warm (not hot) water for 10–15 min should be used. A gentle cleansing bar or wash (e.g. Dove® Sensitive Skin Unscented Beauty Bar, Aquaphor® Gentle Wash, AVEENO® Advanced Care Wash, CeraVe™ Hydrating Cleanser, and Cetaphil® Gentle Cleansing Bar) should only be used as needed. After finishing showering/bathing, the skin should be pat dry (do not rub) and immediately afterwards (within 1–2 min) moisturiser or topical medication should be applied. Fragrance-free moisturisers available in one-pound jars include Vaseline® or Aquaphor® ointment, Eucerin® cream, Vanicream®, CeraVe® cream or Cetaphil® cream. In a study examining the use of moisturisers for the prevention of AD in high-risk newborns, petrolatum was found to be the most cost-effective moisturiser ($353/quality-adjusted life year) in the cohort [79]. When the clinical and cost-efficacy of a glycyrrhetinic acid-containing barrier repair cream (BRC-Gly, Atopiclair®), a ceramide-dominant barrier repair cream (BRC-Cer, EpiCeram®) and an over the counter petroleum-based skin protectant moisturiser (OTC-Pet, Aquaphor Healing Ointment®) were compared as monotherapy for mild-to-moderate AD in children, the results showed that there was no statistically significant difference in efficacy between the three groups at each time point studies, and the OTC-petroleum was at least 47 times more cost-effective [80,81]. Moisturisers should be used liberally at least three times daily. Moisturisers and sealers should not be applied over topical prescription medications as they will dilute the efficacy [81,82].
The versatility of azelaic acid in dermatology
Published in Journal of Dermatological Treatment, 2022
Tamara Searle, Faisal R. Ali, Firas Al-Niaimi
In Yang and colleagues’ study (37), 45 patients with keratosis pilaris were instructed to apply 20% azelaic acid cream to one side of their arm, cheek or leg and Cetaphil cream twice daily to the other side of the contralateral body part for 3 months. 92% of the azelaic acid treated skin and 83% of the cetaphil treated skin showed a significant improvement in hyperkeratosis and or erythema after 3 months (p < .001). There was no difference between both groups (37).