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Vulvar Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Tumors of the vulva comprise (1) epithelial tumors (squamous and related tumors and precursors [squamous cell carcinoma not otherwise specified, or SCC NOS—keratinizing, nonkeratinizing, basaloid, warty, verrucous, keratoacanthoma-like, variant with tumor giant cells; basal cell carcinoma; squamous intraepithelial neoplasia—vulvar intraepithelial neoplasia [VIN] 3 or SCC in situ; benign squamous lesions—condyloma acuminatum, vestibular papilloma or micropapillomatosis, fibroepithelial polyp, seborrheic and inverted follicular keratosis, keratoacanthoma], glandular tumors [Paget disease; Bartholin gland tumors—adenocarcinoma, SCC, adenoid cystic carcinoma, adenosquamous carcinoma, transitional cell carcinoma, small cell carcinoma, adenoma, adenomyoma; tumors arising from specialized anogenital mammary-like glands—adenocarcinoma of mammary gland type, papillary hidradenoma; adenocarcinoma of Skene gland origin; adenocarcinomas of other types; adenoma of minor vestibular glands; mixed tumor of the vulva], tumors of skin appendage origin [malignant sweat gland tumors, sebaceous carcinoma, syringoma, nodular hidradenoma, trichoepithelioma, trichilemmoma]), (2) soft tissue tumors (sarcoma botryoides, leiomyosarcoma, proximal epithelioid sarcoma, alveolar soft part sarcoma, liposarcoma, dermatofibrosarcoma protuberans, deep angiomyxoma, superficial angiomyxoma, angiomyofibroblastoma, cellular angiofibroma, leiomyoma, granular cell tumor), (3) melanocytic tumors (malignant melanoma, congenital melanocytic nevus, acquired melanocytic nevus, blue nevus, atypical melanocytic nevus of the genital type, dysplastic melanocytic nevus), (4) miscellaneous tumors (yolk sac tumor, Merkel cell tumor, peripheral primitive neuroectodermal tumor or Ewing tumor), (5) hematopoietic and lymphoid tumors (malignant lymphoma, leukemia), and (6) secondary tumors [1].
Vulvar angiofibroma: a case report of a rare cause of huge vulvar mass
Published in Journal of Obstetrics and Gynaecology, 2021
Dvir Reder, Fatma Kedan, Simone Garzon, Sergio Haimovich
Cellular angiofibroma (CAF) of the vulva is a rare benign mesenchymal lesion which was first described in 1997 by Nucci et al. (1997) and then in isolated case reports (Mandato et al. 2015; Aydın et al. 2016; Khmou et al. 2016; Kumar et al. 2018). It is a benign neoplasm usually affecting middle-aged women and is usually treated by local excision. It is histologically characterised by a spindle cell component and abundant small-to-medium sized thick-walled vessels (Iwasa and Fletcher 2004). The differential diagnosis is of paramount importance to avoid overtreatment, as well as inadequate surgery. Differential diagnosis includes aggressive angiomyxoma, spindle cell lipoma, mammary type myofibroblastoma, angiomyofibroblastoma, fibrous tumours, perineuroma, fibroepithelial stromal polyp, and leiomyoma (Mandato et al. 2015). Due to the rarity, we report on a case of CAF of the vulva, the used diagnostic flowchart, and the treatment. Moreover, according to our knowledge, this is the biggest case reported in the literature with all the previously reported cases with size under the 20 cm. The ethics approval was obtained from the local Institutional Review Board. The patient provided informed consent to report their data and surgical images of the case.
Cellular angiofibroma of the orbit
Published in Orbit, 2021
G.J. Hötte, R.M. Verdijk, M. Gardeniers, D. Paridaens
Cellular angiofibroma is a benign mesenchymal tumor most commonly located in the distal genital tract of both men (inguino-scrotal region) and women (vulvo-vaginal region).2,3 Extragenital locations have been reported rarely and include the hypopharynx, nasopharynx, oral mucosa, pelvis, hypochondrium, retroperitoneal space, breasts, chest and extremities.3–8 In this report, we present the first case of cellular angiofibroma located in the orbit.