Baboon syndrome

Baboon syndrome

Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis

Published in Anton C. de Groot, Monographs in Contact Allergy, 2021

A 61-year-old woman suffered from a chronic anal fissure for which she applied both an ointment with dibucaine 1% and a cream with 2% diltiazem hydrochloride. The patient reported erythema of the perianal area in the first days, and 5 days later, she presented with a symmetric intertriginous and flexural exanthema. She stopped the medications with complete recovery within 10 days. Patch tests were strongly positive (+++) to the cream and ointment ‘as is’, dibucaine 5% pet. and diltiazem 10% pet. The clinical presentation was that of the baboon syndrome, one of the main presentations of systemic contact dermatitis. The cause was most likely systemic absorption of dibucaine and diltiazem through the anal mucosa and skin (22).

Allergic reactions to penicillins and cephalosporins: diagnosis, assessment of cross-reactivity and management

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Journal Information

Published in Expert Review of Clinical Immunology, 2019

Natalia Blanca-Lopez, Teodorikez Wilfox Jimenez-Rodriguez, Maria L. Somoza, Enrique Gomez, Mona Al-Ahmad, Dolores Perez-Sala, Miguel Blanca

SDRIFE is a symmetrical intertriginous and flexural exanthema considered by some a form of systemic CE. The Baboon syndrome is considered in the same group, characterized by symmetrical skin erythema involving the gluteal and intertriginous areas without systemic involvement [48]. DRESS consists of a cutaneous rash with lymphadenopathy and eosinophilia with more severe cases having thrombocytopenia and abnormal blood lymphocytes. Liver and other organs can be involved [49].

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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis

Allergic reactions to penicillins and cephalosporins: diagnosis, assessment of cross-reactivity and management