China
Africa
Explore chapters and articles related to this topic
Dentin-Pulp Complex Regeneration
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Amaury Pozos-Guillén, Héctor Flores
In the last two decades, advances in biomaterials and clinical research have made different modalities of treatment to treat the dentin-pulp complex possible, allowing manipulation of reactionary and reparative dentinogenesis. The resolution of infection and the disease process remains the primary goal of any endodontic therapy. A repaired tissue that promotes the resolution of disease and re-establishment of some or all of the original tissue functions should be a desirable goal. The goal of regenerative endodontics is the use of biologic-based procedures to arrest the disease process, preventing its recurrence while favoring the repair or replacement of damaged structures of the dentin-pulp complex.
Bioactive molecule carrier systems in endodontics
Published in Expert Opinion on Drug Delivery, 2020
Anil Kishen, Hebatullah Hussein
Regenerative endodontics employs the principles of tissue engineering to regenerate the pulp-dentin complex and allow the root development of immature permanent teeth to continue [1,2]. The conventional approach consists of two- or multi-step procedures, which include disinfection of the root canal space and induction of bleeding from the periapical region to guide stems cells and growth factors into the root canal [3]. The blood clot and dentin walls act as scaffolds and provide growth factors for the generation of neotissue. However, the tissue growth commonly reported in the pulp space is mainly of three types: intracanal cementum along the dentinal walls, periodontal ligament-like tissue, and bone-like tissue that fills the root canal lumen. This ultrastructural architecture is not the presentation of well-regenerated pulp-dentin complex [4]. Thus, based on the histological limitations, there has been a significant interest in the exploration of more effective therapeutic methodologies to enhance dentin-pulp tissue engineering.
Dental stem cells in tooth regeneration and repair in the future
Published in Expert Opinion on Biological Therapy, 2018
Christian Morsczeck, Torsten E. Reichert
The dental pulp contains probably different types of somatic stem cells with unique differentiation potentials. Nakashima and colleagues, for example, isolated a specific sub-population of mobilized DPSCs (MDPSCs) [45,46]. Here, the granulocyte-colony-stimulating factor mobilizes the migration of DPSCs. So MDPSCs could be enriched via a simple cell migration assay. These migrating cells expressed more angiogenic/neurotrophic factors than DPSCs, and their potential to regenerate the dental pulp in an ectopic tooth transplantation assay in mice was higher [46]. Recently, Nakashima and her colleagues used autologous human MDPSCs in a pilot clinical study in pulpectomized teeth with great success. Although this pilot study included only five patients, human MDPSCs are probably safe and also efficacious for complete pulp regeneration therapies [45]. However, the authors also found that a randomized clinical trial with large numbers of patients is necessary before regenerative endodontics becomes a reality [45].
Orthodontic management of a non-vital immature tooth treated with regenerative endodontics: a case report
Published in Journal of Orthodontics, 2018
Zynab Jawad, Claire Bates, Mandeep Duggal, Hani Nazzal
The use of regenerative endodontics in the management of immature teeth, especially following dental trauma, has increased in the past 10 years (Nazzal et al. 2018) especially following the recent published endodontic (American Association of Endodontics 2016; European Society of Endodontology 2016) and paediatric dental guidelines (Duggal et al. 2017). Orthodontic management of such patients is sometimes indicated as in the case presented here. Therefore, it is imperative for orthodontics to take into account both the implications of tooth movement of these teeth and consider the long-term prognosis before embarking on treatment as recommended following conventional endodontically treated teeth (Kindelan et al. 2008).