China
Africa
Explore chapters and articles related to this topic
Triphala
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Studies have confirmed several potential benefits of triphala, which comprise free radical hunting, anti-inflammatory, antioxidant, immune-stimulating, pain alleviating, cicatrizant, gastric hyperacidity decreasing, appetite-stimulating, chemopreventive, antibacterial, dental caries preventing, antipyretic, high blood glucose reducing, antistress, adaptogenic, hepatoprotective and radioprotective effects. The composition of triphala may also encourage appropriate assimilation and absorption of food, decrease cholesterol levels in serum, make the circulation better, relax bile ducts, prevent gradual weakening of the immune system and enhance the production of haemoglobin and RBCs. These myrobalans preserve the process of homeostasis in the endocrine system (Baliga et al., 2012). Triphala has been established to have a radioprotective influence in rats susceptible to γ radiation (Jagetia et al., 2002). Each herb utilised in this composition has numerous other health advantages, such as Terminalia chebula having anticancer, antimutagenic, antimicrobial and anti–dental caries properties and reducing confined anaphylaxis. Emblica officinalis has cytoprotective, anti-inflammatory, antimutagenic, gastroprotective, antioxidant and hypolipidemic activity. Similarly, Terminalia belerica is described to work as a hepatoprotective agent, protect against necrosis of cardiac muscles and diminish fat-stimulated atherosclerosis (Mukherjee et al., 2006).
Bioactive Constituents in Indian Medicinal Plants Traditionally Recognized for Brain Health Benefits
Published in Abhai Kumar, Debasis Bagchi, Antioxidants and Functional Foods for Neurodegenerative Disorders, 2021
Deepak Mundkinajeddu, Amit Agarwal, Gururaja Giligar Manjunatha, Vineet Kumar Singh
This plant is widely distributed in tropical and subtropical parts of countries such as India, China, and Indonesia. Amla is an important Indian medicinal plant in the traditional system of medicine and is native to India. It is one of the three constituents of the famous Ayurvedic preparation called “triphala,” which is prescribed in many health indications. It is a rich source of vitamin C. Amla is mainly cultivated in Uttar Pradesh, Gujarat, Rajasthan, and Tamil Nadu. Brain health benefits of the fruits of Amla have been highlighted in the Indian traditional systems of medicine such as Ayurveda and Unani. In Ayurvedic texts, the plant is mentioned under “Rasayana,” which means it promotes memory, intellect, and vitality in addition to the overall well-being. Neuroprotective and memory-related benefits of the fruits have been well studied in the modern literature (Husain et al., 2019). The fruit exhibits activities such as antioxidant (Khopde et al., 2001), immunomodulatory (Suja et al., 2009), antipyretic, analgesic (Perianayagam et al., 2004), cytoprotective (Ram et al., 2002), antitussive (Nosal’ova et al., 2003), neuroprotective agent (Mathew et al., 2014), memory-enhancing factor, and is involved in treating ophthalmic and gastroprotective disorders (Al-Rehaily et al., 2002) (Table 18.13).
Clinical Research in Ayurveda
Published in Amritpal Singh Saroya, Contemporary Phytomedicines, 2017
A systemic study afforded several single or poly-herbal, and herbo-mineral and purely mineral based formulations used in TIM. Much of the clinical research was related to respiratory and musculoskeletal system. Among polyherbal formulations, guggul- based formulations were the cornerstone for treating arthritis and rheumatism. Use of Triphala was highlighted in various clinical conditions.The major drawback of these clinical studies is lack of control. The studies do emphasize clinical utility of formulations used in TIM, which may be the basis of reinitiating clinical trials. We also believe that instead of an expanding list of novel formulations, work should be initiated to evaluate the potential of already reported formulations to overcome the shortcomings encountered in earlier clinical studies.
Pharmacological effects of Chatuphalatika in hyperuricemia of gout
Published in Pharmaceutical Biology, 2018
Vilasinee Hirunpanich Sato, Bunleu Sungthong, Prasob-Orn Rinthong, Narawat Nuamnaichati, Supachoke Mangmool, Savita Chewchida, Hitoshi Sato
CTPT has a composition similar to triphala, which has been shown to be beneficial for gouty arthritis (Naik et al. 2006; Sabina and Rasool 2008; Kalaiselvan and Rasool 2015). We have reported the pharmacological mechanisms associated with triphala (Sato et al. 2017). Recently, CTPT has been advertised as a food supplement which is beneficial to several diseases, including hyperuricemia in gout. However, mechanistic studies to support these beneficial pharmacological activities (i.e., antihyperuricemic and anti-inflammatory effects) of CTPT have been lacking so far. Therefore, the objectives of the present study were to evaluate the antioxidative and antihyperuricemic effects of CTPT under in vitro and in vivo conditions. In particular, direct in vivo evidence for the effect of CTPT on XOD activity was evaluated using potassium oxonate-induced hyperuricemic mice. An enzyme kinetic analysis using Lineweaver–Burk plots was performed to assess the type of XOD inhibition by CTPT. Moreover, the anti-inflammatory effects of CTPT were determined using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Effect of oral administration of Triphala, a polyphenol-rich prebiotic, on scalp sebum in patients with scalp seborrhea a randomized clinical trial
Published in Journal of Dermatological Treatment, 2022
Elham Zareie, Parvin Mansouri, Hamed Hosseini, Omid Sadeghpour, Laila Shirbeigi, Someyeh Hejazi, Majid Emtiazy
Triphala is an herbal medicinal product that has been used for hundreds of years in traditional and Ayurvedic medicine. To the best of our knowledge, no adverse effect has been reported for Triphala in animal or human studies (20,21,23,31). Clinical trials showed no adverse effects for Triphala consumption (20,22,23). Kamali et al. showed there are no significant changes in renal function or in the liver- associated enzymes in laboratory tests in Triphala group (22). Earlier pre-clinical studies have investigated the safety of Triphala consumption using LD50, MTT, and LDH assays and noted that in doses up to 240 mg/kg, Triphala has no toxic effects (23). The accumulation of heavy metals, including arsenic and lead, was reported at rates below the permitted limits in all formulations (23,37). This clinical trial showed there were no serious adverse effects in the Triphala group, except constipation. The overall patients’ satisfaction with the treatment process in the Triphala group was significantly superior in comparison with the placebo group as well as the observed overall perception of scalp greasiness in the study of probiotic ST11 (12). The study limitation was the lack of quantitative assessment of scalp microbiota. The strengths of our study were the use of Triphala as a well-known and safe herbal medicament in the traditional and Ayurvedic medicine which is available and inexpensive in the Iran pharmaceutical market. To the best of our knowledge the current study was the first clinical study to determine the effect of oral administration of Triphala on the scalp seborrhea. Designing a study to determine the effect of Triphala on the skin microbiota is recommended by authors.