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Plant Sources as Potential Therapeutics for Alzheimer’s Disease
Published in Parimelazhagan Thangaraj, Medicinal Plants, 2018
Azhwar Raghunath, Kiruthika Sundarraj, Vishnu Vignesh Kanagaraj, Ekambaram Perumal
Shilajit is a substance found in the latex of E. royleana Boiss, which has immunomodulatory activities (Pandey and Tewari 1975). Shilajit interacts with the cholinergic signal pathways and therefore can act as a potential therapeutic agent in AD treatment. Shilajit is adaptogenic, immunomodulatory and reduces stress (Winston et al. 2007). These unique properties make it an ideal candidate for the treatment of AD. Shilajit in combination with Withania somnifera influences cholinergic signal transduction cascade in the cortical and basal forebrain (Schliebs et al. 1997). Tau protein buildup is a hallmark of AD. Fulvic acid, the primary constituent of shilajit, strongly inhibited tau protein aggregation and is one of the few polyphenolic compounds that exhibits this property (Guzmán-Martinez et al. 2013). Fulvic acid is not only capable of inhibiting tau filament formation, but it also breaks apart and untangles the tau filaments (Cornejo et al. 2011). In addition, exposure to fulvic acid resulted in the increased neurite outgrowth in the neural cell cultures. This special feature revealed from E. royleana Boiss may open up new possibilities towards AD treatment.
A-Z of Standardisation, Pre-Clinical, Clinical and Toxicological Data
Published in Saroya Amritpal Singh, Regulatory and Pharmacological Basis of Ayurvedic Formulations, 2017
Mineral origin:Shilajit is obtained as exudate from rocks (Rajagopalan 1984; Ghosal 1992). The exudate contains 50% pure Shilajit and the rest are impurities. Sometimes Shilajit is obtained in pure form (Rajnath and Prasad 1942). Shilajit has been described as bitumen varying greatly in consistency from a free flowing liquid to hard brittle solid; a mineral resin, a plant fossil exposed by the elevation of the Himalayas, a substance of mixed plant and animal origin and an inorganic material (Tewari et al. 1973).
Some Rasayana formulations
Published in H.S. Puri, Rasayana, 2002
Method Triturate all inorganic compounds and pastes. Add gum guggal, ghee and Tinospora starch to it, and triturate the whole mixture again until homogenous. Dissolve Shilajit in a small amount of water and mix it in the above mixture. When homogenous make pills of 250 mg each.
Protective effects of L-carnitine on X irradiation-induced uterus injury via antioxidant and anti-inflammatory pathways
Published in International Journal of Radiation Biology, 2023
Serkan Karacetin, Meryem Akpolat, Zehra Safi Oz, Ayse Ceylan Hamamcioglu
Biochemical data of our study demonstrated that TOS and OSI values in LC treated groups declined and TAS values elevated compared to the radiated groups. This implied that LC is an antioxidant agent. According to Kececi et al. (2016), radiation induced damage can cause apoptosis within the follicular cells of the ovarium and can also cause chromosomal damage by inducing oxidative stress. Researchers measured total antioxidant capacity and found that shilajit, an antioxidant agent, increased TAS values after irradiation. Can et al. (2018) reported no significant differences in terms of ovarian TAS and TOS levels at an early period (3 h). Malondialdehyde (MDA) levels were also found to be lower in shilajit treated groups than the control groups, which indicated low levels of lipid peroxidation. It was concluded that shilajit has antioxidant properties and it particularly protects primordial follicles (Kececi et al. 2016). In this study, we also found that calculated oxidative stress index decreased in LC treated groups. LC may protect endometrium by reducing lipid peroxidation within the endometrial epithelial and stromal cells of the rat uterus. This result indicates that LC can be effective against oxidative stress.
A Proprietary Herbal Blend Containing Extracts of Punica granatum Fruit Rind and Theobroma cocoa Seeds Increases Serum Testosterone Level in Healthy Young Males: A Randomized, Double-Blind Placebo-Controlled Study
Published in Journal of Dietary Supplements, 2023
Poorna Gopal Azad Sreeramaneni, Amulya Yalamanchi, Manikyeswara Rao Konda, Sree Harsha Varma Cherukuri, Joseph C. Maroon
This study was designed to provide greater than 80% power to detect a treatment effect in the primary efficacy variable at a two-sided significance level of 5% (α = 0.05). In calculating sample size, a mean difference of 22 pmol/L and a common standard deviation of 28.2 for free testosterone; and a mean difference of 4.9 nmol/L and a common standard deviation of 5.9 for total testosterone was considered. These estimates were based on a clinical study that evaluated the effect of an Ayurvedic ingredient (Shilajit) on testosterone levels in healthy males (20). Based on the power calculation, a minimum of twenty-seven subjects per group was estimated to have 80% power to detect the significant effect of LN18178 supplementation in testosterone level (free and total). This trial recruited one hundred and twenty subjects (forty subjects per group), considering a 10% dropout.
Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit Shows Induction of Microvascular and Extracellular Matrix Mechanisms
Published in Journal of the American College of Nutrition, 2019
Amitava Das, Mohamed S. El Masry, Surya C. Gnyawali, Subhadip Ghatak, Kanhaiya Singh, Richard Stewart, Madeline Lewis, Abhijoy Saha, Gayle Gordillo, Savita Khanna
Shilajit is a resinous blackish-brown sticky tar-like herbo-mineral exudate that seeps from sedimentary rocks of steep mountainous regions and has reported medicinal properties (1, 2). Although geographic and environmental factors determine the composition of shilajit (1, 3), chemical characterization of shilajit has revealed the presence of three major components as represented by dibenzo-α-pyrones (DBPs, also known as urolithins in free form as well as conjugated with chromoproteins), fulvic acid with DBP core nucleus, and humic acid (2, 3). Shilajit and its active constituents have been reported to possess an array of pharmacological properties including adaptogenic, antioxidant, anti-inflammatory, immunomodulatory, anti-diabetic, and neurological properties (4, 5).