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Perspectives of Nature-Oriented Pharmacotherapeutics for the Effectual Management of Hemorrhoidal Symptoms
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Taranpreet Kaur Bamrah, Mojabir Hussen Ansari, Debarshi Kar Mahapatra
Hamamelis virginiana (Witch-Hazel) gel is used in curing hemorrhoids or bleeding piles entirely. Applying a little Witch hazel astringent gel around the rectum can be beneficial in reducing the inflammation, curing the pain, preventing the burning sensation, swelling, and discomfort as well as reducing hemorrhage.
Potential of Phytochemicals in the Treatment of Hemorrhoids
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Besides general treatment, plant-based intestinal regulators and plant-based phlebotonics are usually preferred by patients. The astringent effect of plants is parallel to the anti-hemorrhoidal influence.8 Tannin is a secondary metabolite, which has astringent activity. It is one of the major chemicals of Hamamelis virginiana L., Juglans regia L., Cassia sp., and Quercus sp. There are many herbal remedies in the market, containing mostly Hamamelis virginiana L.47 Besides, anti-inflammatory activity is closely related to capillary permeability related illness. Flavonoid derivatives are also effective for venous diseases such as varicose vein and hemorrhoid.61 Additionally, saponin derivatives isolated from Aesculus hippocastanum L. and Ruscus aculeatus L. are active ingredients in related herbal medicines.
Quorum sensing inhibitors: a patent review (2014–2018)
Published in Expert Opinion on Therapeutic Patents, 2018
Xin Chen, Likun Zhang, Mingxiang Zhang, Huayu Liu, Panrui Lu, Kejiang Lin
Zhao et al. found that a pharmaceutical composition of marine and herbal organisms, namely, Syngnathus sp, Ecklonia kurome, Sophorae flavescentis Radix, Lonicerae Japonicae Flos, Isatidis Folium, Phellodendri chinensis Cortex and Caryophylli Flos, demonstratedd the potential of treating various bacterial infection with little resistance [102]. Li et al. discovered that an extract of Moutan Cortex disrupted the QS system of Pseudomonas fluorescens, which kept fishery products fresh [103]. Sugiyama et al. found that a mixture of polypeptides and lipids originating from Lactobacillus plantarum SN35N inhibited TSST-1 production of S. aureus [104]. Tufenkji et al. illustrated that phenolic-rich maple syrup extract, combined with antibiotics also possesses antimicrobial potential [105]. Other extracts from plants such as Carex dimorpholepis [106], Cercis chinensis [107], Citrus junos [108], Myristica fragrans [109], Schinus terebinthifolia [110], Vaccinium macrocarpon [111], Styrax paralleoneurus, and Styrax tonkinensis [112] can inhibit biofilm formation and interfere with QS to control the growth of microorganisms. Jia et al. found that stilbenoids, namely, resveratrol, piceatannol and oxyresveratrol inhibit C. violaceum [113] and P. aeruginosa QS [114]. The bis-benzyl-tetrahydro-isoquinoline compounds from Plumula nelumbinis were also shown to inhibit the QS of different strains of P. aeruginosa [115]. In addition, hamamelitannin, a natural compound found in Hamamelis virginiana HAM analogue has been reported to be a potential QSI in 2007, but it had several drawbacks. As a result, Coenye et al. developed some 250 analogues of hamamelitannin that can also disrupt bacterial QS [116].