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Biomarkers for Quality Control of Chinese Tonifying Herbs and Herbal Health Products
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
In response to the increasing sale of Chinese herbal products on the retail market in China, traditional Chinese herbal medicines (and their related products and preparations) are regulated under the ‘Provisions of Drug and Registration’ as well as the ‘Guideline for Protection of Traditional Chinese Medicinal Products’ by the China Food and Drug Administration (Teng et al. 2016). Currently, the quality of Chinese herbal products is regulated under the National Drug standards (Teng et al. 2016), which is based on the standards listed in the Chinese Pharmacopoeia (2015 edition). In general, quality assurance can be determined using two possible approaches – namely, the use of chemical markers and fingerprinting. While the chemical marker approach relies on the identification and quantification of individual compound(s) in an herbal preparation, the fingerprinting approach makes use of unique chromatographic profile/patterns determined by liquid and/or gas chromatography analysis of an herbal preparation (Zhang et al. 2011). A manufacturer is required to submit evidence for assuring the quality and safety of an herbal product before its approval for marketing.
Complementary therapies
Published in Wesley C. Finegan, Angela McGurk, Wilma O’Donnell, Jan Pederson, Elizabeth Rogerson, Care of the Cancer Patient, 2018
Wesley C. Finegan, Angela McGurk, Wilma O’Donnell, Jan Pederson, Elizabeth Rogerson
As with Chinese herbal medicine, there can be many impurities in herbal medicines and they are not regulated. There is great potential for interaction with prescribed medicines, and no way of checking the precise formulation of the product, as ingredients may be altered or exchanged and may be misleadingly documented on the packaging. Allergic reactions, drug interactions and toxic reactions have all been reported.
Acupuncture and Traditional Chinese Medicine
Published in Mark V. Boswell, B. Eliot Cole, Weiner's Pain Management, 2005
Traditionally, Chinese herbal medicine has been used in Asia for a wide range of acute and chronic pain conditions such as osteoarthritis, rheumatoid arthritis, cervicalgia, low back pain, headache, fibrositis and myositis, neuritis, and other pain conditions. Herbal drugs have been shown to exert antioxidant activity, modulate cytokines and chemokines, effect gene expression, and regulate the inflammatory cascade. Modern Chinese herbal preparations include concentrated extracts, standardized dry extracts, and injectable medications. Numerous traditional Chinese herbal medicines have been shown to have analgesic and anti-inflammatory activity in the laboratory and in animal models. These include Panax ginseng radix, Scutellaria radix, Aconiti radix, Stephaniae tetrandrae radix, and others.
Comprehensive viewpoints on heart rate variability at high altitude
Published in Clinical and Experimental Hypertension, 2023
Jun Hou, Keji Lu, Peiwen Chen, Peng Wang, Jing Li, Jiali Yang, Qing Liu, Qiang Xue, Zhaobing Tang, Haifeng Pei
In recent years, the benefits of combining Chinese herbal medicines with Western medicines in clinical practice have become increasingly prominent. For instance, the combination of metoprolol with Wenxin granule or Yindan Xintai Dropping Pills has shown improvements in the time domain indicators of HRV (138,139). Similarly, the combination of ginkgo damole with mecobalamin, rhodiola with levocarnitine, and Xinkeshu in combination with metoprolol have demonstrated effectiveness in improving both time-domain and frequency-domain indicators of HRV (140–142). Although existing studies have identified numerous drugs for the prevention and treatment of high altitude hypoxia-related diseases, the specific mechanisms involved are not yet fully understood, and there is a scarcity of research involving HRV. Further extensive experimentation is still required.
Lack of pharmacokinetic interaction between derazantinib and naringin in rats
Published in Pharmaceutical Biology, 2023
Ya-nan Liu, Jie Chen, Xinhao Xu, Yingying Hu, Jin-yu Hu, Ren-ai Xu, Guanyang Lin
After the progress of first-line systemic chemotherapy of iCCA, derazantinib monotherapy showed good safety and good antitumor activity in the population of patients with iCCA, with a daily dose of 300 mg. Naringin, as a kind of traditional Chinese medicine component that can promote immunosuppression and repair renal injury, has great medical potential in combination with derazantinib. This reminds us that in the treatment of difficult and miscellaneous diseases, we could pay more attention to the role and application of Chinese herbal medicine and its main components in the first-line clinic, and combined medication is a good choice. In this study, we firstly established a reliable, rapid and robust UPLC-MS/MS method to quantify the concentration of derazantinib in rat plasma. At the same time, UPLC-MS/MS method was successfully applied to the pharmacokinetics of derazantinib with or without potent antitumor agent naringin in rats. And, the results displayed that there was no drug-drug interaction between naringin and derazantinib in rats.
Efficacy and Clinical Significance of the Zuogui Pill on Premature Ovarian Failure via the GDF-9/Smad2 Pathway
Published in Nutrition and Cancer, 2023
Su Cen, Xiaojun Qian, Chunfang Wu, Xinya Xu, Xiaohui Yang
Chinese herbal medicine is usually integrated with other medicines to form a formulation for the treatment of POF [31]. Chinese herbal medicine is capable of maintaining homeostasis and improving circulation and microcirculation in the body, thereby further controlling neuroendocrine function and enhancing hormone levels based on Chinese dialectical therapy [32]. The combination of traditional Chinese and Western medicine can improve therapeutic efficacy and reduce the side effects of chronic hormone use, thus promoting ovarian function recovery [33]. Our study results revealed that in patients with POF patients treated with ZGP and Femoston, the FSH, LH, IL-6, and IL-21 levels, and the PI and RI values decreased, while the E2 and AMH levels, and the AFC, OV, MOD, and PSV values increased. A previous study demonstrated that a decline in follicular function leads to reduced ovarian estrogen and progesterone levels, and elevated serum FSH and LH levels [34]. High FSH and low E2 expression are characteristic of POF [35]. As previously reported, herbal medicines can improve serum E2, FSH, and LH levels [36]. Similar to our findings, Peng et al. have shown improved estrous cycles, ovarian ultrastructures, numbers of follicles and corpora lutea, reduced FSH levels, and elevated E2 levels after treatment with ZGP [4]. All these findings suggest the therapeutic effect of herbal medicine on POF.