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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Astragalus membranaceus is the species of Astragalus used in traditional Chinese medicine. It is alternatively known as A. propinquus or A. mongholicus. As is typical in the Chinese tradition, Astragalus membranaceus has generally been used as part of combinations of herbs for treatment of various illness. It has most commonly found use in treatments of what are seen as in TCM as spleen and lung deficiencies contributing to diarrhea, fatigue, poor appetite, sweating, colds, shortness of breath, and various wasting disorders. However, given the role thought to be played by the spleen meridian in symptoms of fatigue and despondency, Astragalus membranaceus has also been part of what might be considered antidepressant treatments, such as Gui Pi Wan, or Restore the Spleen Pills, and Bu Zhong Yi Qi Wan, or Pill to Strengthen the Center and Boost Qi.1
Mode of Action of Selected Botanicals That Lower Blood Glucose
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
Astragalus membranaceus is an important herb in traditional Chinese medicine. It has been used in a wide variety of herbal blends and “natural” remedies, including Dang-gui buxue tang, which is A. membranaceus paired with Angelicae sinensis.
Astragaloside IV suppresses inflammatory response via suppression of NF-κB, and MAPK signalling in human bronchial epithelial cells
Published in Archives of Physiology and Biochemistry, 2022
Hsi-Lung Hsieh, Shih-Hai Liu, Ya-Ling Chen, Chien-Yi Huang, Shu-Ju Wu
Astragalus membranaceus is mainly grown in China. Traditional Chinese medicine uses A. membranaceus as an important herbal medicine for promoted qi expression (Bai et al.2018). In recent years, scholars discovered that A. membranaceus has the ability to regulate immunity (Huang, Luo, et al.2019). Astragaloside IV was isolated from A. membranaceus, and astragaloside IV was thought that could inhibit inflammatory response of macrophage via blocked NF-κB, MAPK signalling pathways (Li et al.2017). Astragaloside IV induced apoptosis and arrested cell proliferation in cancer cells (Cheng et al.2014, Jiang et al.2017). Astragaloside IV could also attenuate cigarette smoke-induced lung inflammation in mice (Meiqian et al.2018). Moreover, researchers also found that astragaloside IV could reduce the airway inflammatory response via blocked the excessive activation of Th2 cells in asthmatic mice (Du et al.2008, Qiu et al.2014). However, astragaloside IV regulated inflammatory response in tracheal epithelial cells is elusive. In this study, we evaluated the anti-inflammatory and anti-oxidation effect of astragaloside IV and the signalling mechanism of the NF-κB, MAPK and HO-1 pathways in bronchial epithelial cells.
Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Yaobin Zhu, Xin Qian, Jingjing Li, Xing Lin, Jiewei Luo, Jianbin Huang, Zhao Jin
Astragalus membranaceus has been used in Chinese traditional medicine for more than 2000 years. It has been widely used with the aim of promoting qi, detoxifying and promoting pus drainage and granulation. Medicinal astragalus is the root of A. membranaceus (Fisch.) Bunge var. membranaceus and A. membranaceus (Fisch.) Bunge var. mongholicus (Bunge) P. K. Hsiao. Astragaloside IV (AS-IV) is a highly effective triterpenoid saponin isolated and purified from A. membranaceus. The molecular formula of AS-IV is C41H68O14 (Figure 1). AS-IV has been reported to show antioxidative stress properties, and to affect immune modulation, including anti-viral and anti-inflammatory effects [1–3]. AS-IV has various mechanisms to protect the myocardium, including an antioxidant and free radical removal function [4]. Astragalus has a detoxification and muscle regeneration role in the treatment of long-term muscle ulcers, indicating that astragalus functions as a scavenger in tissue and organ repair and regeneration. We hypothesized that one of the important pharmacological action of astragalus is to participate in cell autophagy.
Astragaloside inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice
Published in Immunopharmacology and Immunotoxicology, 2019
Hongtao Li, Yufei Peng, Xiuzhen Wang, Xiaowei Sun, Fangjun Yang, Yufeng Sun, Bo Wang
Recently, abundant reports showed that some traditional Chinese medicine (TCM) or their monomer could maintain or improve the joint function [10,11]. Astragalus membranaceus is a Traditional Chinese medicine commonly used for treating a wide range of diseases and body disorders. Astragaloside is the effective chemical component of astragalus membranaceus with immunomodulating, anti-oxidant, anti-inflammatory and anti-cancer activities [12–14]. Furthermore, astragaloside is proven to effectively suppress excessive expression of inflammatory cytokines, such as IL-6 and TNF-α [15]. Moreover, astragaloside suppresses inflammation partly via damping NF-κB signal [16–18]. In the current study, we investigated the potential effect of astragaloside in OA which might provide evidence in clinical.