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Plant-Based Essential Oils in The Treatment of Microbial Infections
Published in Mahendra Rai, Chistiane M. Feitosa, Eco-Friendly Biobased Products Used in Microbial Diseases, 2022
Hercília Maria Lins Rolim, Alessandra Braga Ribeiro, Monalisa de Alencar Lucena, Andressa Barros Ibiapina, Thais Cruz Ramalho
The EO from some species, that are already commonly used in popular medicine, have shown an interesting profile regarding their antimicrobial activity, with emphasis on the species Annona foetida (“araticum caatinga”), Annona muricata Lin., Hypericum spp. (the species H. brasiliense being the most common in Brazil), Rhaphiodon echinus (Nees & Mart.) Schauer (“betônica”) and Vanillosmopsis arborea Barker (“candeeiro”) (Costa et al. 2009; França et al. 2009; Kuete et al. 2016; Costa et al. 2017; Rodrigues et al. 2018). The few studies on these species showed the unexploited potential antimicrobial activity of their bioactive compounds. In this point of view, further investigation of their EO must be carried out in order to obtain new sources of natural compounds for application in various industrial sectors, including pharmaceutical fields.
In Silico approach of soursop leaf for prediction of anticancer molecular target therapy
Published in Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah, Medical Technology and Environmental Health, 2020
M.K. Dewi, Y. Kharisma, L. Yuniarti
Annona muricata Linn (Annonaceae), commonly known as soursop or graviola, is in the Annonacea family. Some phytochemicals that are reported to have been isolated and characterized from various parts of the soursop plant are annonaceous acetogenins, lactones, isoquinoline alkaloids, tannis, coumarins, procyanidins, flavonoids, pentacyclic terpenoids saponins, p-coumaric acid, myristic acid, stepharine, reticulags, reticulins, ellicags, reticulins, and iced phytosterol (Chen et al. 2012, Liu et al. 2012). The first generation of annonaceous acetogenin mimetic (1, AA005) not only shows antitumor activity in some human cancer cells in vitro but also has high selectivity between normal cells and cancer cells (Qayed et al. 2015, Liang et al. 2009). Flavonoids have cytotoxic effects and selective apoptotic induction activity in vitro on squamous cell carcinoma HSC-2, submandibular gland carcinoma HSG. Tannins have a selective in vitro cytotoxic effect on human T cell lines, human oral squamous cell carcinomas, and salivary gland tumor cell lines rather than normal human gingival fibroblasts with activity inducing apoptosis (Watson & Preedy 2010, Chin 2009).
Research on Medicinal Plants for Malaria
Published in Woon-Chien Teng, Ho Han Kiat, Rossarin Suwanarusk, Hwee-Ling Koh, Medicinal Plants and Malaria, 2016
Woon-Chien Teng, Ho Han Kiat, Rossarin Suwanarusk, Hwee-Ling Koh
In view of this, priority for further research could be also given to the 14 plants from the current study found to be used in four continents for malaria (excluding the two Cinchona species): Allium sativum, Caesalpinia bonduc, Capsicum frutescens, Carica papaya, Cissampelos pareira, Coffea arabica, Eucalyptus globulus, Leonotis nepetifolia, Momordica charantia, Mangifera indica, Senna occidentalis, and Sida acuta, four of which are mentioned in the list by Willcox and Bodeker. Annona muricata, Sida rhombifolia, Jatropha curcas, and Zingiber officinale, which are mentioned to be used in three tropical continents in 2004, are also reported in the current study to be used in three continents. Ricinus communis and Senna tora are reported to be used in two continents and one continent, respectively, in the current study; whereas Kalanchoe pinnata is not reported in the current list, probably owing to different search strategies and sources used. It is of note that the IVmal system included plants used to treat fever. In the current study, plants solely used for fever other than “malarial fever” were excluded, for the purpose of having a more conservative definition of medicinal plants used for malaria.
Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability, and in vitro efficacy
Published in Pharmaceutical Development and Technology, 2021
Daniele M. de Oliveira, Diego B. Menezes, Lucas R. Andrade, Felipe da C. Lima, Luciana Hollanda, Aleksandra Zielinska, Elena Sanchez-Lopez, Eliana B. Souto, Patrícia Severino
Najmuddin et al. evaluated the cytotoxic and antitumor profiles of Annona muricata crude extract samples against, respectively, breast cancer cell lines and a tumor-bearing mice model(Syed Najmuddin et al. 2016). The authors reported that the selectivity of the extract to specific receptors promoted the reduction of the tumor size, also showing an anti-metastatic effect with induced apoptosis both in vitro and in vivo. The extract showed antioxidant properties by reducing the level of nitric oxide and malondialdehyde in the tumor while also increased the level of white blood cells, T-cell, and natural killer cell population. These properties can be attributed to the presence of polyphenols as they are known to be responsible for the antioxidant activity in fruits and leaves. If the anti-oxidant activity of S. terebinthifolius Raddi has already been validated and may be recommended in pharmaceutical formulations for the treatment of diseases involving oxidative stress.
Antitumour activity of Annona muricata L. leaf methanol extracts against Ehrlich Ascites Carcinoma and Dalton’s Lymphoma Ascites mediated tumours in Swiss albino mice
Published in Libyan Journal of Medicine, 2021
Aditi Venkatesh Naik, Shanti N. Dessai, Krishnan Sellappan
Our study demonstrates the potency of Annona muricata L. methanolic leaf extracts showing in-vitro and in-vivo antitumour activity without major changes in toxicity parameters evaluated. We found a dramatic decrease in cell viability and increased protection against experimental animals from the deleterious effect of DLA/EAC induced tumour in mice exerted by LEAM in a dose-dependent manner. However, in comparison with different concentrations of leaf extract tested, 500 mg/kg b.wt. dose of LEAM regressed tumour growth and prolonged survival in mice. Hence, it is proved that A. muricata leaf methanol extracts possessed potent antitumour activity. This indicates that the leaf may potentially provide better bioactive compounds with substantial anti-proliferative characteristics that could be useful in primary healthcare. However, to support the above, further investigations are being carried out to elucidate the exact mechanism of action and its metabolism studies.
In vitro evaluation of Annona muricata L. (Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells
Published in Biomarkers, 2020
Aditi Venkatesh Naik, Krishnan Sellappan
Annona muricata L. is a flowering plant species within the family Annonaceae; widely found in the world’s tropical and subtropical regions, including parts of Africa, America and Asia (Anuragi et al.2016). All organs of this plant are used as ethnomedicine or phytochemical biomarkers to treat diverse diseases and maladies (Moghadamtousi et al.2015a). The plant components have been thoroughly studied till date for their valuable pharmacological properties, embodied by extracts or isolated compounds and were found most effective in the treatment of cancer along with other ailments (Gavamukulya et al.2017, Qazi et al.2018). According to literature, the leaves of A. muricata contain 117 isolates of secondary metabolites consisting primarily of alkaloids, phenolic compounds, megastigmanes and annonaceous acetogenins (Matsushige et al.2012, Coria-Téllez et al.2018).