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Prospects of Local Flora of Trans-Himalayan Region of Ladakh for Various Medicinal Uses
Published in Parimelazhagan Thangaraj, Medicinal Plants, 2018
Gyan P. Mishra, Tsering Stobdan, Parimelazhagan Thangaraj, Tania Seth, Bijendra Singh
Sea buckthorn oil is a valuable product used in medicine as a nutraceutical supplement and in cosmetics. Lipids from sea buckthorn leaves have been recommended for anti-burn and wound healing properties. The presence of a high content of α-tocopherol has significant healthful effects which act as natural antioxidants in the human body. The carotenoid content of sea buckthorn oil ranges from 314–2139 mg/100g (Zhang et al. 1989). It is indicated that the carotenoids consist of approximately 20% β-carotene, 30% γ-carotene, 30% lycopene and 15% oxygen-containing carotenoids. Phytosterol is also constituents of sea buckthorn oil which are capable of lowering plasma cholesterol on consumption by humans. The major phytosterol is sitosterol (β-sitosterol) and 5-avenasterol. The total quantity of phytoesterol in whole sea buckthorn fruits ranges from 340–520 mg/kg and is 4 to 20 times more than soybean oil. A novel triglyceride, 1,3-dicapryloyl-2-linoleoyl glycerol has been isolated and its structure was elucidated by Swaroop et al. (2005).
Ospemifene efficacy and safety data in women with vulvovaginal atrophy
Published in Gynecological Endocrinology, 2020
Lino Del Pup, Rafael Sánchez-Borrego
In summary, ospemifene has an efficacy comparable to or superior to that of other treatments for VVA. A systematic, indirect comparison of ospemifene versus LET for vulvar and vaginal atrophy suggests that 60 mg of ospemifene has an efficacy, safety, and tolerability profile comparable to or better than that of LET for the treatment of VVA [46]. This result is further confirmed by a recent meta-analysis [47] suggesting that 60 mg of ospemifene is associated with significant improvement in the morphological and physiological features of the vaginal mucosa that correlate with the symptoms associated with postmenopausal VVA. A systematic review with a network meta-analysis of randomized controlled trials [48] concluded that compared with a placebo, bazedoxifene, conjugated estrogens, soy isoflavone vaginal gel, sea buckthorn oil and estriol vaginal gel, ospemifene had the greatest therapeutic effect, based on the percentage of superficial and parabasal cells and on symptoms of dyspareunia and vaginal dryness.