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Honey and Its Immunostimulatory Activities
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Royal jelly is utilised in the feasting of queen bees and larvae as an exceptional nutrient, which is released from the mandibular and hypopharyngeal glands of worker bees (Matsuoka et al., 2012; Strant et al., 2019). Royal jelly is one of the bee products having a somewhat complicated structure. In its constitution, elements that target numerous identified and unidentified biological mechanisms play a significant role in the biomedical outcome of the royal jelly (Stocker et al., 2005). Royal jelly is enriched with vitamins, proteins, hormones, minerals, sugars and fatty acids needed for the evolution of the larvae. It comprises lipids (3–6%), minerals (3–8%), carbohydrates (9–18%), protein (18%), water (60–70%), salt and vitamins; it also consists of various bioactive compounds that have immunity-boosting properties, such as peptides and 10-HDA (10-hydroxy-2-decenoic acid) (Margaoan et al., 2017; Premratanachai & Chanchao, 2014; Strant et al., 2019). An RCT study has stated that royal jelly is found to be beneficial in decreasing the symptoms of premenstrual syndrome (Taavoni et al., 2014). Another randomised controlled clinical study described the efficacy of royal jelly in the management of problems of the urinary tract and for enhancing the quality of life in postmenopausal women (Seyyedi et al., 2016).
Animal Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Royal jelly may possess numerous functional properties such as antibacterial activity, anti-inflammatory activity, vasodilative and hypotensive activities, disinfectant action, antioxidant activity, anti-hypercholesterolemic activity, and antitumor activity and might enhance longevity in humans by promoting general health (132, 141–142). In addition, this product has demonstrated its efficiency in the alleviation of postmenopausal complaints (142). However, the exact mechanism through which royal jelly may extend lifespan is not well-understood (132). The biological activities of royal jelly are mainly attributed to its bioactive fatty acids, proteins, and phenolic compounds (141). Royal jelly may cause allergy such as asthma in some hypersensitive people.
Role of Process Standardisation in Development of Natural Products
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Arunporn Etherat, Romanee Sanguandeekul, Panadda Nontahnum, Pimpinan Somsong, George Srzednicki
Royal jelly is normally consumed as a fresh product. Due to its nourishing composition, it is easily degraded. Fresh royal jelly can be stored in a refrigerator (4°C) for a few days and can be kept frozen at the temperature of at least −18°C for a year. For longer shelf life, it should be freeze-dried.
Royal jelly arranges apoptotic and oxidative stress pathways and reduces damage to liver tissues of rats by down-regulation of Bcl-2, GSK3 and NF-κB and up-regulation of caspase and Nrf-2 protein signalling pathways
Published in Biomarkers, 2023
Abdullah Aslan, Ozlem Gok, Seda Beyaz, Gozde Parlak, Muhammed Ismail Can, Ramazan Gundogdu, Serpil Baspinar, Ibrahim Hanifi Ozercan, Akif Evren Parlak
Royal jelly (RJ) is excreted by the hypopharyngeal and submandibular glands of young worker bees, and it is a traditional product widely used to support the medical treatment of various diseases (Kanbur et al.2009, Elewa et al. 2019). It is a viscous substance with a whitish-yellow colour. It consists of different bioactive materials such as carbohydrates, lipids, proteins, free amino acids, vitamins and mineral salts (Mohamed et al. 2015, Park et al. 2020). Accumulating evidence demonstrates that royal jelly has anti-oxidant, anti-diabetic, anti-bacterial, anti-tumour, anti-allergic, anti-inflammatory, hypocholesterolemic, hypotensive, anti-aging, anti-fatigue, neuroprotective and wound healing properties (Elewa et al. 2019, Mostafa et al. 2020). Due to its antioxidant activity, royal jelly was shown to prevent the effects of oxidative stress and lipid peroxidation and protects DNA against oxidative stress (Jalili et al. 2019). In addition to its therapeutical potentials, royal jelly is widely used in cosmetics, healthy foods and commercial medicinal products in many countries (Zhang et al. 2017).
Exploring the functionalization of Ti-6Al-4V alloy with the novel antimicrobial peptide JIChis-2 via plasma polymerization
Published in Biofouling, 2023
Gabriella Teresinha Lima Teixeira, Rogério Valentim Gelamo, Malu Mateus Santos Obata, Leonardo Eurípedes de Andrade Silva, Marcos Vinícius da Silva, Carlo José Freire de Oliveira, Brunela Pereira da Silva, Idalina Vieira Aoki, Jeferson Aparecido Moreto, Natália Bueno Leite Slade
Among the AMPs there are the Jelleines that make up a family of peptides, found in royal jelly, endowed with high antimicrobial action (Fontana et al. 2004). Royal jelly is an acidic secretion produced in the hypopharyngeal and mandibular glands of young worker bees (Ramanathan et al. 2018). The royal jelly has several other therapeutic properties, such as: antitumor, anti-inflammatory, anti-hypercholesterolemic, and hypotensive, among others (Cornara et al. 2017). Fontana et al. (2004) isolated four peptides from honeybee royal jelly, named Jelleine I, Jelleine II, Jelleine III and Jelleine IV. Thus, three of these peptides (Jelleines I-III) showed antimicrobial activity against a wide spectrum of Gram-positive and Gram-negative bacteria (Fontana et al. 2004). Recently, Petrin et al. (2019) presented a chitosan functionalization strategy with different short-chain amino acid peptides. Among these, the conjugation of JIChis-I, a peptide analogue of Jelleine-I, with chitosan exhibited superior antimicrobial activity to Jelleine-I for E. coli and S. aureus (Petrin et al. 2019)
Protective effect of royal jelly on fluoride-induced nephrotoxicity in rats via the some protein biomarkers signalling pathways: a new approach for kidney damage
Published in Biomarkers, 2022
Abdullah Aslan, Seda Beyaz, Ozlem Gok, Muhammed Ismail Can, Gozde Parlak, Ramazan Gundogdu, Ibrahim Hanifi Ozercan, Serpil Baspinar
Royal jelly affects the function of immune cells positively by exhibiting various biological activities with its anti-inflammatory and antioxidant properties. It has been determined that royal jelly has immunomodulatory effects especially on kidney and liver tissues (Pourmobini et al.2021). Royal jelly is the special food of queen honey bee (Apis mellifera) larvae, and it is secreted from the under-pharynx glands of worker honey bees. This substance, which has a viscous structure with a unique odour and a burning taste, contains 50-60% water, 18% protein, 15% carbohydrate, 3-6% lipid, 1.5% mineral salt and various vitamins. It also contains biologically active substances such as pretin, biopretin, neopretin, xanthopretin, which are widely used by humans and provide cell renewal, vigour and vitality. It is also rich in hormones, B vitamins and essential fatty acids. Royal jelly is widely used in pharmaceutical industry because it was shown to prevent high blood pressure, to regulate kidney and urinary tract diseases, to relieve mental and physical fatigue, and to be effective against wrinkles and acne on the skin (Sever 2014, Ghanbari et al.2015).