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Therapeutic Uses of Phycocolloids
Published in Leonel Pereira, Therapeutic and Nutritional Uses of Algae, 2018
Water-in-oil emulsions such as mayonnaise and salad dressings are less likely to separate into their original oil and water phases if thickened with alginate. Sodium alginate is not useful when the emulsion is acidic, due to insoluble alginic acid forms. For these applications, propylene glycol alginate (PGA) is used since this is stable in mild, acidic conditions. Alginate improves the texture, body, and sheen of yoghurt, but PGA is also used in the stabilization of milk proteins under acidic conditions, as found in some yoghurts. Some fruit drinks have fruit pulp added, and it is preferable to keep this in suspension. The addition of sodium alginate, or PGA in acidic conditions can prevent sedimentation of the pulp and create foam (hence it’s used in creating the “head” on certain beers). In chocolate milk, the cocoa can be kept in suspension by an alginate/phosphate mixture, although in this application, it faces strong competition from another seaweed gel, i.e., carrageenan. Small amounts of alginate can thicken and stabilize whipped cream (Nussinovitich 1997, Onsoyen 1997).
Effect of sulfobutyl ether-β-cyclodextrin and propylene glycol alginate on the solubility of clozapine
Published in Pharmaceutical Development and Technology, 2019
Takayuki Furuishi, Kohei Sekino, Mihoko Gunji, Kaori Fukuzawa, Hiromasa Nagase, Tomohiro Endo, Haruhisa Ueda, Etsuo Yonemochi
The aim of this study was to examine various formulation approaches, as well as binary and ternary CD complexes made with β-CD and three different β-CD derivatives (Me-, 2-HP-, and SBE-β-CD) with respect to their ability to improve the solubility of the poorly soluble drug, CLZ. PVP, HPMC, carboxymethylcellulose sodium salt (CMC), polyvinyl alcohol (PVA), sodium alginate (ALG), and propylene glycol alginate (PGA) were chosen as the water-soluble polymers. The study included phase solubility studies, continuous variation method, and NMR measurements of the product to determine the interaction between the drugs and additives.
Enamel matrix derivative does not affect osteoclast formation or bone resorption in cultures of mouse bone marrow macrophages or human monocytes
Published in Acta Odontologica Scandinavica, 2022
Susanne Lindquist, Catrine Isehed, Anita Lie, Pernilla Lundberg
Emdogain® is supplied in 0.3-mL vials at a concentration of 30 mg/mL (Straumann AG, Basel, Switzerland). To remove the acidic propylene glycol alginate (PGA) gel and obtain a neutral pH, the contents of one vial were dialysed against 1× PBS (pH 7.4) and diluted 12-fold to a final concentration of 2.5 mg/mL prior to use in cell experiments.