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The Potential of Food Nutrients in the Prevention and Amelioration of Cognitive Dysfunction Caused by Neurodegenerative Diseases
Published in Abhai Kumar, Debasis Bagchi, Antioxidants and Functional Foods for Neurodegenerative Disorders, 2021
Cognitive impairment caused by advancing age is a worldwide catastrophic health problem. Aging is the utmost risk factor for brain health. No single active drug is available for the prevention and treatment of neurodegenerative diseases. Thus, early preventive measures against this age-related disorder are important, and dietary factors may play an especially important role. A series of research studies on nutrition and cognition shows that the appropriate intake of foods and nutrients has proven to be effective to slow the aging process, improve health, and slow the onset of neurodegeneration [1,6,15].
Association of dietary inflammatory index and leukocyte telomere length with mild cognitive impairment in Chinese older adults
Published in Nutritional Neuroscience, 2023
Qian Liu, Dongtao Zhou, Huilian Duan, Yun Zhu, Yue Du, Changqing Sun, Hongyan Lin, Mengdi Jin, Jingzhu Fu, Yuxia Gao, Fei Ma, Yongjie Chen, Meilin Zhang, Guowei Huang
This study analyzed data from Tianjin Elderly Nutrition and Cognition Cohort (TENCC) study (Clinical Trials Registration Identifier: ChiCTR2000034348), an ongoing China elderly population-based prospective cohort study focused on the relationship between nutrition and cognitive health. Briefly, participants were recruited from the Baodi area of Tianjin, China. They were sufficiently competent in walking, vision and hearing to complete assessments, and were aged 60 years or older at enrollment from March 2018 to June 2019. Using a multistage cluster sampling approach, we selected three communities in Baodi District. From the three communities, we identified a total of 5547 eligible subjects. People who were willing to participate in the dietary survey were included in the present analysis (n = 4019). Subjects who did not undergo a fasting blood collected (n = 22), had a history of cerebral stroke (n = 84) or cancer (n = 13), severe mental illness (n = 25), Parkinson’s disease (n = 7) and Alzheimer’s disease (AD) (n = 1) were excluded. In addition, subjects who had missing data on basic characteristics (n = 105) or FFQ information (n = 254) or lacking test on LTL (n = 122) were excluded. As a result, 3386 subjects were assessed in this study (Figure 1). The Ethics Committee of the Tianjin Medical University approved the study protocol (approval/protocol number: TMUhMEC2018013). Written informed consent was obtained from all participants.
The use of magnetic resonance spectroscopy for assessing the effect of diet on cognition
Published in Nutritional Neuroscience, 2018
Claire J. Scavuzzo, Christopher J. Moulton, Ryan J. Larsen
Magnetic resonance imaging (MRI) is important for characterizing brain health and cognition, and is used to study how environmental factors such as nutrition may influence the status of the brain.1,2 A variety of MRI techniques provide complementary information on the integrity of brain tissue and the supporting vascular network, and have revealed relationships between nutrition and cognition. For example, structural MR imaging can characterize brain atrophy in aging populations, which is related to reduced plasma levels of vitamins B, C, D, and E.3 Structural MRI is also useful for probing the health of white matter: T2-weighted imaging can be used to identify poorly vascularized regions known as white matter hyperintensities (WMH), which are so named due to their pronounced contrast in MR images.4 WMHs have been associated with low omega-3 fatty acid (FA) status3 and lower choline intakes.5 Nutritional influence on cerebral blood flow can also be characterized by using MR techniques that directly measure profusion of blood into brain tissue. Arterial spin labeling has been used to demonstrate the acute benefits of dietary flavonoids in promoting the profusion of blood in gray and white matter.6 The health of white matter can also be characterized using MR measurements of water diffusion and magnetic relaxation, or the rate at which magnetically excited molecular states decay. These relaxometry measurements can be used to detect the volume of water associated with myelin, and therefore are sensitive to brain development and have been used to characterize differences between breast-fed and formula-fed infants.7
Cancer-related cognitive impairment: current perspectives on the management of cognitive changes following cancer treatment
Published in Expert Review of Neurotherapeutics, 2023
Giulia Binarelli, Mylène Duivon, Florence Joly, Djihane Ahmed-Lecheheb, Marie Lange
Another lead that is beginning to be explored is the role of nutrition on cognition and cognitive decline. Some preliminary results suggest that the intake of foods rich in antioxidants and omega-3 PUFAs (i.e. fruits, vegetables and fish) could be beneficial for CRCD [112]. However no sufficient evidence are available to offer recommendations concerning nutrition [113].