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Pharmacological Properties of Mulberry (Morus Alba)
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Morus alba L. (white mulberry) usually originated from Asia and is used for sericulture in India, China, Vietnam, and Korea. It is also known as the “folk sacred fruit”. The mulberry trees have been extensively scattered throughout the world representing different species, which are native to other countries, such as America, Arabia, China, India, Japan, North Africa, South Europe, and Taiwan etc. It is a medium sized tree about 30 m in height and monoecious or deciduous tree with large stems bearing bark. This species is indigenous to China and is also found in hilly areas of Himalayas. This species has been used in China as a remedy to various diseases.
Nutraceutical Herbs and Insulin Resistance
Published in Robert E.C. Wildman, Richard S. Bruno, Handbook of Nutraceuticals and Functional Foods, 2019
Giuseppe Derosa, Pamela Maffioli
Morus alba L. belongs to the family Moraceae; it is native to China and also widely cultivated in Japan and Korea. The species is a fast-growing tree, which can reach up to 20 meters in height. In Korea and Japan, patients with diabetes consume mulberry leaves as an anti-hyperglycemic supplement. Studies reported in literature seem to suggest that the leaf extract has significant post-prandial hypoglycemic effect, possibly through the inhibition of α-glucosidase and glucose transport.61
Functional Foods Continued
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
So far as it can be determined, no such restriction, or content labeling, is required by FDA regulations for products that are a tea or an “extract” herbal supplement. Thus, until this matter is clarified, it would be extremely unwise for anyone with poor kidney function to undertake glycemia control with any form of Morus alba.
Chemical compositions of Commiphora opobalsamum stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage
Published in Biomarkers, 2022
Mai M. Farid, Asmaa F. Aboul Naser, Maha M. Salem, Yomna R. Ahmed, Mahmoud Emam, Manal A. Hamed
In the current study and in agreement with the results of Akbarzadeh et al. (2007) and Hussein et al. 2012), the diabetic rats showed an elevation in the blood glucose and α-amylase levels, as well as a significant drop in insulin levels. Treatment with Commiphora opobalsamum butanol fraction improves BGL, insulin and α- levels as compared with the reference drug; Glibenclamide. These results was confirmed by the observation of Jäger et al. (2009) who sated that the secondary metabolites present in leaves, seeds, fruits, and plant roots as triterpenes and phenols had anti-diabetic effect and exert its action through the anti-diabetic pathways. By inhibiting α-amylase, α-glucosidase, and pancreatic lipase; triterpenes can block enzymes in the glucose metabolism pathway and reduce insulin resistance as well as the plasma glucose level (Oboh et al. 2021). Assiri et al. (2017) added that the mechanism of antidiabetic action of the bioactive compounds in Morus alba are involve in the intracellular pathways of insulin signalling or glucose homeostasis.
Mulberry fruit improves memory in scopolamine-treated mice: role of cholinergic function, antioxidant system, and TrkB/Akt signaling
Published in Nutritional Neuroscience, 2021
Suk Kyung Shin, Jae-Myung Yoo, Fu Yi Li, Seong Yeon Baek, Mee Ree Kim
Mulberry fruit, the fruit of Morus alba L., has some beneficial properties, such as anti-allergy [11], antioxidant, and anti-diabetes [12]. The biological actions of mulberry fruit are closely related with various phytochemicals, such as anthocyanins [13], polysaccharides [14], phenolic acids [15], and flavonoids [11]. Recently, it was reported that the antioxidant activity of an ethyl acetate fraction of mulberry fruit extract (MFE) was stronger than that of other solvent fractions, such as those of hexane, chloroform, n-butanol, and water as well as that of a 70% ethanol extract [12]. In addition, ethanol extract of mulberry fruit, which is rich in anthocyanins, has been reported to exhibit potent neuroprotective actions [16–18]. Although the antioxidant activity of MFE is stronger than that of an ethanol extract of mulberry fruit, there is no report concerning protection of neuronal cells against oxidative stress-mediated neurodegeneration.
Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d -galactose-induced aging mice
Published in Pharmaceutical Biology, 2016
Nergiz Hacer Turgut, Derya Guliz Mert, Haki Kara, Hatice Reyhan Egilmez, Emre Arslanbas, Bektas Tepe, Huseyin Gungor, Nese Yilmaz, Necati Baris Tuncel
Morus nigra L. (Moraceae) is known as black mulberry. Almost all parts of this tree are used for pharmacological effects (Naderi et al. 2004; Singab et al. 2005; Imran et al. 2010). Morus nigra leaves have been used to stimulate insulin production for diabetes in Europe (Ode 2000) and has been reported to reduce incidence of internal anomalies in offspring from diabetic dams (Volpato et al. 2011). In addition, it is reported to have neuroprotective effects against cerebral ischemia (Kang et al. 2006), to improve inflammation-related hematological parameters in arthritic rats (Kim and Park 2006), to have potential antiobesity and antidiabetic effects in HF diet-induced obesity (Lim et al. 2013), and to have free radical scavenger effects (Isabelle et al. 2008). Recently, due to its high-bioactive content, M. nigra is believed to be a more healthy fruit among mulberry species (Orhan and Ercisli 2010).