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The Treatment of Hypertension with Nutrition, Nutritional Supplements, Lifestyle and Pharmacologic Therapies
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Hesperidin significantly lowered DBP by 3–4 mmHg (p < 0.02) and improved microvascular endothelial reactivity in 24 obese hypertensive male subjects in a randomized, controlled, crossover study over 4 weeks for each of three treatment groups consuming 500 mL of orange juice, hesperidin or placebo [382].
Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan
Hesperidin, commonly found in the citrus family, is of greater pharmacological significance as a powerful anti-inflammatory and anti-diabetic bioactive. It is a commonly available drug across the world used for treating vascular dilation (Haggag et al. 2020). In COVID-19 research, hesperidin helps in triggering the host immune system and acts as an antiviral bioactive in other respiratory-related viral infections. Hesperidin, customarily used in Chinese traditional medicine, is also shown to display antitumour effects against a broad spectrum of tumours, especially breast cancer, by downregulating few genes in signalling pathways necessary for cancer cell growth, multiplication, and metastasis (Kongtawelert et al. 2020).
Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, Sarwar Beg
Hesperidin is a citrus flavonoid reported for its wide variety of pharmacological effects. The therapeutic effect of hesperidin is well investigated in the adjuvant rat arthritis model. At the 80, 160 mg/kg dose of hesperidin inhibits significantly the secondary paw swelling and down regulates production of IL-1, IL-6, and TNF-a in RA rats. Another research has shown that hesperidin has a significant impact of suppressing synoviocytes’ proliferation in rat adjuvant arthritis model.
Comparison of the effects of methylprednisolone, hyperbaric oxygen and hesperidin + diosmin on the facial nerve injury: an experimental animal model
Published in Acta Oto-Laryngologica, 2023
Yaşar Özbuğday, Mehmet Erkan Kahraman, Abdullah Arslan, Ilknur Küçükosmanoğlu
Hesperidin + Diosmin, is effectively used as a vasoprotective agent in varicose veins, hemorrhoids and lymphedema. This agent reduces capillary permeability and edema, and increases blood flow at the tissue level [12,13]. The effects of hesperidin, one of the components of HD, can be attributed to many mechanisms such as free radical scavenging, suppression of inflammation, inhibition of enzymes responsible for free radical formation and facilitating the endogenous antioxidative defense system [13,14]. In addition, it has been shown in animal studies that hesperidin protects neuronal cells in various regions of the brain against ischemia, stroke, and oxidative-induced damage [15]. In our study, which we designed based on the positive effects of flavonoids on microcirculation and their potential neuroprotective activities in central nervous system studies, we observed the positive effects of HD on traumatic FN injury, both histopathologically and functionally. This potential positive effect and mechanism of action needs to be demonstrated by further studies in animals and humans.
Cardioprotective effects of hesperidin on carbon monoxide poisoned in rats
Published in Drug and Chemical Toxicology, 2021
Ramin Rezaee, Alireza Sheidary, Saeedeh Jangjoo, Sarvenaz Ekhtiary, Somayeh Bagheri, Zahra Kohkan, Madjid Dadres, Anca Oana Docea, Konstantinos Tsarouhas, Dimosthenis A. Sarigiannis, Spyros Karakitsios, Aristidis Tsatsakis, Leda Kovatsi, Mahmoud Hashemzaei
Hesperidin belongs to a flavonoid subgroup of citrus flavonoids. It possesses a variety of anti-oxidant, anti-inflammatory, anti-aging, blood lipid and cholesterol lowering and anti-tumorigenesis properties (Parhiz et al. 2015, Pari et al. 2015, Bahramsoltani et al. 2019, Fouad et al. 2019). In addition, hesperidin has protective effects against cardiac ischemia/reperfusion (He et al. 2017). Furthermore, hesperidin has the ability to inhibit cardiac hypertrophy and fibrosis, oxidative stress and myocytes’ apoptosis induced by pressure overload, offering protection against cardiac dysfunction (Deng et al. 2013). Among various signaling proteins, protein kinase B (PKB, also known as Akt) appears to be a central player in metabolism regulation, cell survival, motility, and transcription as well as cell cycle (Fayard et al. 2005). Moreover, this protein is a key protein in pathways of myocardial salvation (Fayard et al. 2005).
Solid self-microemulsifying nutraceutical delivery system for hesperidin using quality by design: assessment of biopharmaceutical attributes and shelf-life
Published in Journal of Microencapsulation, 2021
Shailesh S. Chalikwar, Sanjay J. Surana, Sameer N. Goyal, Kaushalendra K. Chaturvedi, Pankaj V. Dangre
Hesperidin (HES) being a nutraceutical has a wide range of therapeutic benefits (Li et al.2008). It is a flavones glycoside and mostly occurs in citrus fruits (Garg et al.2001). It has been reported to possess hypoglycaemic (Akiyama et al.2009), hypolipidemic (Wilcox et al.2001), anticancer (Stanisic et al.2018), antioxidant and anti-inflammatory (Yang et al.2012), and vasoprotective (Garg et al.2001) activities. These activities are consociated to inhibit HMG-CoA reductase, phospholipase A2, lipooxygenase, cyclooxygenase (Bok et al.1999, Hirata et al.2005). Despite various therapeutic activities, HES is scarcely soluble in water (<0.01%), (Yamada et al.2006) which restrict its application as a potent nutraceutical. Furthermore, a reasonable elimination half-life (6 h) (Li and Schluesener 2017), low oral bioavailability (<25%) and gastric instability (Sansone et al.2009) also restrict its application.