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The Look and Feel of Food
Published in Alan R. Hirsch, Nutrition and Sensation, 2023
Sanford S. Sherman, Mary Beth Gallant-Shean, Alan R. Hirsch
In an opposite fashion, astringent rinses, as with grape seed extract, reduce oral lubrication sensation (fattiness and slipperiness). This possibly accounts for why astringent beverages, like tea or red wine accompanying a fatty meal, result in an oral sensation of “cleanliness” (Peyrot des Gachons, and Breslin 2011).
Natural Product Compounds from Plants in Neurodegenerative Diseases
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Priya Darshani, Md TanjimAlam, Prem P. Tripathi, V.S. Pragadheesh
Anthocyanin-rich elderberry juice, which exhibits anti-inflammatory and antioxidant properties and improves mitochondrial function, stands as a therapeutic agent in phase II of clinical trials. Grape seed extract, which contains polyphenolic compounds and acts as an anti-oligomerization agent and prevents aggregation of amyloid and tau protein, is another therapeutic agent in the pipeline for the treatment of AD (Cummings et al., 2019). Korean red ginseng is used as an adjuvant treatment because of its neuroprotective and anti-inflammatory effects (Fei et al., 2020). Ginseng extracts play diversified roles in modulating the signaling pathways through their multidimensional effect on nuclear factor kappa beta (NF-κB), MAP kinase and LPS-induced activation of the STAT signaling pathway. The antioxidant activity of soy isoflavone glycitein, which is the most recognized biologically active compound in soybeans and soy products, may inhibit Aβ aggregate deposition, consequently affecting Aβ-related neurodegenerative disease (Fei et al., 2020).
The Treatment of Hypertension with Nutrition, Nutritional Supplements, Lifestyle and Pharmacologic Therapies
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Grape seed extract (GSE) produces a significant reduction in BP in clinical trials and in meta-analyses [2–5,328–332]. A meta-analysis of 9 randomized trials with 390 subjects administered GSE in variable doses and variable amounts of resveratrol demonstrated a significant reduction in SBP of 1.54 mmHg (p < 0.02), but no reduction in DBP [328]. Significant reduction in BP of 11/8 mmHg (P < 0.05) occurs with a dose of 300 mg/day in 1 month [329]. In a meta-analysis of 16 clinical trials in 2016 with 810 subjects [331], there were significant reductions in BP with GSE 6/3 mmHg (p = 0.001) especially in young patients and those with obesity or metabolic syndrome [331]. A single-center, randomized, two-arm, double-blinded, placebo-controlled, 12-week parallel study was conducted in 36 middle-aged adults with prehypertension [332]. Subjects consumed a juice containing placebo or 300 mg/day GSE, 150 mg twice daily, for 6 weeks preceded by a 2-week placebo run-in and followed by 4-week no-beverage follow-up [332]. GSE significantly reduced SBP by 5.6% (P = 0.012) and DBP by 4.7% (P = 0.049) [332]. BP returned to baseline after the 4-week discontinuation period of GSE beverage. The higher the initial BP, the greater the response.
Effect of Combined Grape Seed Extract and L-Citrulline Supplementation on Hemodynamic Responses to Exercise in Young Males
Published in Journal of Dietary Supplements, 2023
Brian Shariffi, Katherine Dillon, Trevor Gillum, William Boyer, Sean Sullivan, Esther Lee, Jong-Kyung Kim
Nutritional supplements that are rich in polyphenols lead to an increase in NO bioavailability via activation of eNOS (20). Administration of dietary grape seed extract (GSE) has been shown to increase the production of NO via activation of eNOS and in turn improve endothelial function in humans with prehypertension and endothelial dysfunction (21–23). Acute administration of GSE has been reported to improve O2 delivery due to endothelium-dependent vasodilation during dynamic exercise in prehypertensive individuals (21). In this regard, dietary GSE supplementation may be a good ergogenic aid for increasing oxygen delivery to exercising muscles. However, the potential beneficial effects of GSE supplement on physiological responses have not been assessed in young, healthy individuals.
Natural products for the management of the hepatitis C virus: a biochemical review
Published in Archives of Physiology and Biochemistry, 2020
Walid Hamdy El-Tantawy, Abeer Temraz
Grape seed extract (GSE) has been widely used as a dietary supplement because of its many bioactivity properties, including antioxidant, hepatoprotective, neuroprotective, cardioprotective, anticancer, anti-inflammatory, anti-aging, and antimicrobial effects (Bagchi et al.2014, Olaku et al.2015). The inhibitory effect of GSE on HCV replication has been studied. The GSE treatment shows significant anti-HCV activity and suppresses HCV-elevated cyclooxygenase-2 (COX-2) expression. In contrast, exogenous COX-2 expression gradually attenuates the antiviral effects of GSE, suggesting that GSE inhibits HCV replication by suppressing the aberrant COX-2 expression caused by HCV, which is correlated with the inactivation of the IKK-regulated NF-κB and MAPK/ERK/JNK-signaling pathways. In addition, GSE attenuates HCV-induced expression of inflammatory cytokine genes (Chen et al.2016b). GSE contains large amounts of phenolic compounds, including gallic acid, (+)-catechin, epicatechin, dimeric procyanidin, quercetin and proanthocyanidins which display anti-HCV activity (Shi et al.2003, Chen et al.2012, Khachatoorian et al.2012). Additionally, procyanidin B1, the main oligomers in GSE (more than 74%), suppresses HCV replication (Bentivegna and Whitney 2002, Li et al.2010).Collectively, these findings suggest the possibility that GSE may be developed as a dietary supplement to treat patients with a chronic HCV infection (Chen et al.2016a).
Grape seed proanthocyanidins and metformin combination attenuate hepatic endoplasmic reticulum stress in rats subjected to nutrition excess
Published in Archives of Physiology and Biochemistry, 2019
Baskaran Yogalakshmi, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha
Grape seed extract has been shown to inhibit α-amylase and α-glucosidase (Yilmazer-Musa et al. 2012), induce tyrosine phosphorylation of insulin receptor (Montagut et al.2010) and promote glucose transporter-4 (GLUT-4) translocation in a phosphoinositide 3-kinase (PI3K) and p38 mitogen-activated protein kinase (p38 MAPK)-dependent manner (Pinent et al. 2004). GSP exert potent gastroprotective activity through the activation of prostaglandin and NO (Brzozowski et al. 2005). GSP has been known to up-regulate the anti-apoptotic protein Bcl-2, down-regulate the pro-apoptotic proteins p53 and Bax (Liu et al. 2016), and reported to promote cardioprotection by suppressing the proapoptotic signals mediated through c-JUN and c-fos (Bagchi et al. 2003).