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Anti-Hyperglycemic Property Of Medicinal Plants
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Karanpreet Singh Bhatia, Arpita Roy, Navneeta Bhardavaj
Emblica officinalis with a vernacular name Indian Gooseberry or Amla, belongs to Phyllanthaceae family and natively from Indian Subcontinent. In one study aqueous extract of fruits of amla showed improvement in OGTT in insulin independent hyperglycemic rats after four weeks of feeding and remarkable decrease in FBG levels after 8 weeks (Ansari et al., 2014). In another study, methanolic extract of E. officnialis consists of quercetin and quercetin was found to be a major contributing factorin reduction of blood glucose level by 14.78% (0.075 g/kg) after one week of treatment. Quercetin extracted from methanolic extract also improved HDL, LDL, triglycerides, and total cholesterol levels at a dose of 0.05 and 0.075 g/kg body weight (Srinivasan et al., 2018).
Triphala
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Studies have confirmed several potential benefits of triphala, which comprise free radical hunting, anti-inflammatory, antioxidant, immune-stimulating, pain alleviating, cicatrizant, gastric hyperacidity decreasing, appetite-stimulating, chemopreventive, antibacterial, dental caries preventing, antipyretic, high blood glucose reducing, antistress, adaptogenic, hepatoprotective and radioprotective effects. The composition of triphala may also encourage appropriate assimilation and absorption of food, decrease cholesterol levels in serum, make the circulation better, relax bile ducts, prevent gradual weakening of the immune system and enhance the production of haemoglobin and RBCs. These myrobalans preserve the process of homeostasis in the endocrine system (Baliga et al., 2012). Triphala has been established to have a radioprotective influence in rats susceptible to γ radiation (Jagetia et al., 2002). Each herb utilised in this composition has numerous other health advantages, such as Terminalia chebula having anticancer, antimutagenic, antimicrobial and anti–dental caries properties and reducing confined anaphylaxis. Emblica officinalis has cytoprotective, anti-inflammatory, antimutagenic, gastroprotective, antioxidant and hypolipidemic activity. Similarly, Terminalia belerica is described to work as a hepatoprotective agent, protect against necrosis of cardiac muscles and diminish fat-stimulated atherosclerosis (Mukherjee et al., 2006).
Role of Amla (Emblica officinalis) in Peptic Ulcer
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Dilipkumar Pal, Souvik Mukherjee
Ethnopharmacology of Emblica officinalis includes12,15,23: laxative, erysipelas, stomachic, digestive, antipyretic, diuretic, ophthalmopathy, aphrodisiac, cephalalgia, and carminative.
Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
Published in Nutrition and Cancer, 2022
Gaurav Kumar, Venkateshwar Madka, Gopal Pathuri, Vishal Ganta, Chinthalapally V. Rao
Many plant extracts, as well as chemicals purified from them, have demonstrated medicinal properties, and have been used to develop numerous traditional herbal therapies demand for which is continuously increasing worldwide. More than 110 thousand plant extracts or purified molecules have been screened for their anticancer efficacy since the start of a National Cancer Institute (NCI) screening program (1). Approximately 25 percent of all medications prescribed in the United States were developed from plants (2), including paclitaxel (commonly known by the tradename Taxol) which is derived from the bark of the Pacific yew tree and may be the most widely used anticancer medication. Similarly, gooseberry (Phyllanthus emblica, Emblica officinalis, or Amla) is an important herbal medicine, commonly used in the Ayurvedic and Unani systems of medicine in South Asia and Arab nations. Different parts of the P. emblica tree have various therapeutic applications in these systems of medicine, including: improving the immune system, treating constipation, reducing stomach acidity, treating stomach ulcers, purifying the blood, and treating diarrhea, dysentery, helminthic infections, diabetes, and cancer (3).
The Prevention and Therapy of Osteoporosis: A Review on Emerging Trends from Hormonal Therapy to Synthetic Drugs to Plant-Based Bioactives
Published in Journal of Dietary Supplements, 2019
Twinkle Gupta, Nilanjan Das, Sabiha Imran
Indian gooseberry (Emblica officinalis) is a deciduous tree belonging to the family Euphorbiaceae. Among its properties are antitussive, antiatherogenic, renoprotective, and neuroprotective activity (Baliga & Dsouza, 2011; Shanker, 1969; Mirunalini & Krishnaveni, 2010). Extracts of Emblica officinalis fruits possess free radical–scavenging properties and are thus studied for possible treatments of diseases such as osteoporosis and rheumatoid arthritis (Penolazzi et al., 2008). E. officinalis extract does not have inhibitory effects on the development of tartrate-resistant acid phosphatase (TRAP) (Ullmann, Bendik, & Flühmann, 2005) and does not cause any cytotoxic effects. The ability of E. officinalis extract to interfere with NF-kB binding to DNA has also been investigated. It has been found that the extract of E. officinalis is a strong inducer of apoptosis of osteoclasts. Moreover, it is also found that extract of E. officinalis possesses a similar inhibitory effect on human cells as biphenylcarboxylic acid, butanediol ester, and genistein.
Augmented Reversal of Cisplatin-Induced Delayed Gastric Emptying by Amla (Emblica Officinalis) Fruit Extract in Sprague-Dawley Rats
Published in Journal of Dietary Supplements, 2018
Asad Ahmad, Mohammad Khushtar, Ranjan Kumar, Ambreena Riyaz, Mohammad Irfan Khan, Azizur Rahman
Pandey and Pandey (2011) performed acute toxicity studies in rats using doses of 250, 500, and 1,000 mg/kg body weight and found that there was no mortality up to 48 hours and the lethal dose (LD50) for the drug EEEO was above 1,000 mg/kg body weight. On the basis of such acute toxicity studies, the two optimal doses of EEEO, 250 and 500 mg/kg body weight, were taken in the present study to evaluate the effect of Emblica officinalis fruit extract (EEEO) on cisplatin-induced delayed gastric emptying in Sprague-Dawley rats (Pandey and Pandey, 2011). Results of the present study indicate that cisplatin-induced delayed gastric emptying was significantly reversed by pretreatment with a high dose of Emblica officinalis fruit extract (500 mg/kg/day). The antioxidant effects of Emblica officinalis are reported by many workers (Gaire and Subedi, 2014; Krishnaveni and Mirunalini, 2012; Singh et al., 2012; Yang and Liu, 2014). Thus, this reversal may be due to the strong antioxidant properties of Emblica officinalis and its phytochemicals such as gallic acid, emblicanin-A, and emblicanin-B having free radical–scavenging activities (Yang and Liu, 2014). Results of the present study indicate that a low dose of Emblica officinalis fruit extract (250 mg/kg/day) did not significantly reverse the cisplatin-induced delay in gastric emptying whereas its high dose (500 mg/kg/day) reversed it. From the extrapolation of the graph plotted between percentage gastric emptying and EEEO dose in laboratory work sheet, it was found that the EEEO dose between 800 and 850 mg/kg/day might perform the same magnitude of activity as that of ondansetron (3 mg/kg/day). Ineffectiveness of low-dose EEEO may be due to the lower quantity of antioxidant constituents (Sharma and Gupta, 1997). Preliminary trials suggest that EEEO augments cisplatin's anticancer effect (Singh et al., 2012). Thus, Emblica officinalis has the dual benefits of being an inhibitor of cisplatin-induced delayed gastric emptying and an adjunctive anticancer agent.