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Effervescent Granulation
Published in Dilip M. Parikh, Handbook of Pharmaceutical Granulation Technology, 2021
Lubricant substances, known as suitable for effervescent manufacturing, are sodium benzoate, sodium acetate, l-leucine, and carbowax 4000. Combinations of lubricants have also become a possibility. Literature reports calcium and potassium sorbates and micronized polyethylene glycol (PEG) with calcium ascorbate or trisodium citrate [29]. Spray-dried l-leucine and PEG 6000 are also considered as a successful mix [30]. Other lesser soluble lubricants are still however used in formulating effervescent tablets. In any case for good lubrication, a balance should be found between compression efficiency and water solubility. Magnesium stearate is commercially available in combination with sodium lauryl sulfate, a surfactant agent that helps in dispersion [31].
Herbal and Supplement Use in Pain Management
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
Dosing: Osteoarthritis: vitamin C in the form of calcium ascorbate 1 gram daily for 2 weeks has been used.57Postoperative pain: a single prophylactic dose of 2 grams of vitamin C by mouth, 1 hour prior to anesthesia has been used in patients (tested in patients receiving cholecystectomy).58
Vitamin C (Ascorbic Acid)
Published in Luke R. Bucci, Nutrition Applied to Injury Rehabilitation and Sports Medicine, 2020
One factor not considered in great detail is that various forms of ascorbate are available commercially. Vitamin C is available as ascorbic acid, sodium ascorbate, calcium ascorbate, mixtures of other minerals with ascorbates (zinc, magnesium, manganese, copper, iron), esterified ascorbate (polymers of calcium ascorbate), and any conceivable combination of the above forms. Thus, it is possible to coadminister essential minerals along with ascorbate. Mineral ascorbates are thought to provide a buffering capacity to reduce acidity of ascorbate and, thus, reduce potential gastrointestinal distress from large doses of ascorbate. The forms of tablets, capsules, powders, and effervescent products added to foods mean that ascorbate supplementation is quite flexible.
Broad spectrum micronutrient formulas for the treatment of symptoms of depression, stress, and/or anxiety: a systematic review
Published in Expert Review of Neurotherapeutics, 2020
Meredith Blampied, Caroline Bell, Claire Gilbert, Julia J. Rucklidge
This systematic review has focused on the use of combinations of micronutrients (specifically vitamins and minerals) used to treat symptoms of depression, mood, anxiety, and stress in unmedicated adults. Challenges to reviewing this literature include the variety of supplementation formulas used, both in terms of doses and also forms of nutrients used (e.g. vitamin C as ascorbic acid, calcium ascorbate, and sodium ascorbate). Many formulas also contained botanicals, amino acids, and sometimes EFAs, presenting a challenge for interpretation as well as elucidating mechanisms. In addition, trials used varying timeframes for supplementation between 1 hour and 12 months, and variability in terms of psychometrics used to assess change in mental functioning and variable populations. Studies were often underpowered, as noted by the authors, which further diminished the ability to draw firm conclusions or make clinical recommendations. Despite this variability, sufficient generalities exist to provide some guidance and potential for clinical recommendations.