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Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Angelica or Radix Angelicae Sinensis (also named Dong Quai or Danggui in Chinese) is the dried root of Angelica sinensis (Apiaceae) which is a fragrant and perennial herb native to China, Japan, and Korea. It has been used in Chinese traditional medicine since antiquity (291–293). The chemical constituents of the Angelica extract are classified into essential oil and water-soluble parts. The volatile oil is constituted of many alkyl phthalides (ligustilides) and some terpenes. The water-soluble part or non-volatile fraction includes phenylpropanoids (ferulic acid, coniferyl ferulate), phenolic compounds, carbohydrates, organic acids, benzenoids, and coumarins. Polysaccharide fractions of low relative molecular mass are also present (291–293). In traditional Chinese medicine, Angelica root replenishes blood, promotes blood circulation, relieves pain, and moistens the intestines. It is used to treat chronic constipation and menstrual disorders (291–293). Research has found that Angelica and its active components have anti-hypertensive, antioxidant, anti-arthrosclerotic, and anti-inflammatory properties (293). However, the therapeutic properties of Angelica are still not approved by the Food and Drug Administration or the World Health Organization. Angelica should not be administered to children or patients with diarrhea, hemorrhage or hypermenorrhea, and should not be used during pregnancy or lactation (291–292). Some side effects such as headaches have been observed. Dried crude powder and fluid extracts of Angelica root are the two forms orally used (291–292).
Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Angelica archangelica L. is an aromatic, perennial herb that grows up to 2 meter tall. The plant is native to the temperate regions of Asia (Caucasus, Siberia), northern, middle and east Europe, and the Himalayas, and has become widely naturalized in northern temperate regions. The plant is cultivated in Italy, Germany, Finland, Hungary, and several other countries including Korea, India and North America (GRIN Taxonomy for Plants; www.kew.org). Commercial angelica root and fruit oils are mostly obtained from cultivated Angelica archangelica L. ssp. angelica var. sativa (10). Essential oils of the fruits (often incorrectly referred to as ‘seeds’, as the seeds are contained within the fruits) and roots of Angelica archangelica are used for healing purposes, as spice and as fragrance component in perfumery (7) and cosmetics. Angelica root oils are also part of aromatherapy practices (9). The biological activities and medicinal uses of Angelica archangelica L. have been reviewed in references 6 and 8.
Examples of TCM formulas used in Chinese medicine
Published in Raymond Cooper, Chun-Tao Che, Daniel Kam-Wah Mok, Charmaine Wing-Yee Tsang, Chinese and Botanical Medicines, 2017
Raymond Cooper, Chun-Tao Che, Daniel Kam-Wah Mok, Charmaine Wing-Yee Tsang
The formula is best suited for conditions of deficiency of yang qi which results in blood stasis (stagnation of blood flow); it is recommended for stroke, paralysis, lower limb atrophy, facial paralysis, etc. In this formula, the Astragalus root aids qi movement, while the Angelica root promotes blood circulation, aided by Ligusticum and Paeonia. The inclusion of the Carthamus flower, apricot kernel, and earthworm further helps remove blood stasis and clear the blocked channels. Thus, the overall action of the formula is strong qi tonifying together with a blood-moving effect.
Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy
Published in Drug Delivery, 2022
Xue Liu, Zhenfeng Wu, Chunjing Guo, Huimin Guo, Yanguo Su, Qiang Chen, Changgang Sun, Qingming Liu, Daquan Chen, Hongjie Mu
Polysaccharides of Chinese traditional medicine have received considerable attention as an abundant resource to be utilized in drug development and disease treatment (Cao et al., 2018; Wang et al., 2020a). ASP, as one of the main polysaccharides extracted from the Angelica root, has anti-tumor and anti-inflammatory activities. At the same time, ASP has a high affinity for ASGPR and MR of hepatoma carcinoma cells (Zhang et al., 2018; Du et al., 2020), so it is expected to become a natural product for the preparation of liver-targeted carrier materials (Du et al., 2020). In this paper, an ASP-based nanocarrier was prepared by a self-assembling method in order to achieve liver targeting. With the introduction of ASP, the amphiphilic polymer micelles can specifically target the liver and reduce the damage to normal cells.
LC-MS/MS detection of citrus unshiu peel-derived flavonoids in the plasma and brain after oral administration of yokukansankachimpihange in rats
Published in Xenobiotica, 2019
Mikina Takiyama, Takashi Matsumoto, Junko Watanabe
The dry powdered extracts of YKSCH (Lot No. 331005900) and YKS (Lot No. 321017700) used in the present study were supplied by Tsumura & Co. (Tokyo, Japan). As shown in Supplementary Table 1, YKSCH is composed of nine crude drugs, including CUP (3 g, peel of Citrus unshiu Markovich) and PT (5 g, tuber of Pinellia ternata Breitenbach), as well as YKS, which contains the following seven crude agents: Atractylodes lancea rhizome (4 g, rhizome of Atractylodes lancea De Candolle), Poria sclerotium (4 g, sclerotium of Wolfiporia cocos Ryvarden et Gilbertson), Cnidium rhizome (3 g, rhizome of Cnidium officinale Makino), Uncaria hook (3 g, hook of Uncaria rhynchophylla Miquel), Japanese Angelica root (3 g, root of Angelica acutiloba Kitagawa), Bupleurum root (2 g, root of Bupleurum falcatum Linné), and Glycyrrhiza (1.5 g, root and stolon of Glycyrrhiza uralensis Fisher).
Saffron and its derivatives, crocin, crocetin and safranal: a patent review
Published in Expert Opinion on Therapeutic Patents, 2018
Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
A Chinese invention introduced an oral medicinal preparation for treating chloasma, upon observing efficacy in clinical-trial studies. It comprises Dahurian angelica root, C. sativus, Rhizoma Corydalis, Herba Selaginellae, Millettia dielsiana, Radix Morindae officinalis, Cuscuta chinensis Lam., Rhizoma Alismatis, Achyranthes bidentata, radix bupleuri, Semen Euryales, Radix Pseudostellariae, cassia twig, Fructus Citri sarcodactylis, Concretio Silicea Bambusae, Cornus officinalis, Manyprickle acathopanax Root, Styrax, Assorted Chinese Herbal Tea, myrrh, pawpaw, Rheum franzenbachii Munt., Cryptotaenia japonica Hassk., honeysuckle stem, Achillea sibirca, Rabdosia rubescens, Lithospermum erythrorhizon, and Radix Scrophulariae [193]. In addition to the effect of saffron on the indicated disorders, the function of this medical herb has been implicated in anticancer formulations [184,185] for treating lung tumor [184] and breast cancer [185].