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Chest Trauma, Iatrogenic Trauma including drainage tubes and some Post-surgical Conditions and Complications of Radiotherapy.
Published in Fred W Wright, Radiology of the Chest and Related Conditions, 2022
An intercostal incision which extends posteriorly may damage the long thoracic nerve leading to atrophy of the serratus anterior and a 'wingedscapula'. Similarly damage to the thoracodorsal nerve may lead to atrophy of the latissimus dorsi (see Goodman, P. et al., 1993 and Frola et al., 1995); this muscle may also be deformed after cardiomyoplasty, when it is 'wrapped around the heart' to increase vascularity. See also Bhalla et al. (1994) - Surgical flaps in the chest.
Minimally Invasive Heart Failure Surgery
Published in Theo Kofidis, Minimally Invasive Cardiac Surgery, 2021
Dynamic cardiomyoplasty used to performed by wrapping the heart with the latissimus dorsi muscle and stimulating the muscle to assist contraction. It appears that those who can survive the operation do not need it, and those who need it, cannot survive it [8].
Overview of Mechanical Circulatory Support
Published in Wayne E. Richenbacher, Mechanical Circulatory Support, 2020
In order to understand the role of mechanical circulatory support in the continuum of care provided to patients with heart failure it is helpful to briefly review therapeutic modalities available to heart failure patients (Table 1.4). The medical management of heart failure has improved dramatically in recent years with the introduction of beta-blockers and angiotensin-converting enzyme inhibitors.6,7 Although somewhat more controversial, with little literature evidence to support an increase in survival, chronic home inotrope infusion therapy and intermittent outpatient inotrope infusion have been offered to heart failure patients. Surgical modalities available to heart failure patients include high risk myocardial revascularization and valve replacement. Coronary artery bypass is increasingly offered to patients with low ejection fractions who have evidence of viable myocardium based upon thallium scans and positron emission tomography. Cardiac transplantation, the mainstay of surgical care for patients with end stage cardiomyopathy is limited by a persistent shortage of donor hearts and limited long-term survival in patients who undergo cardiac transplantation secondary to complications of immunosuppressive therapy and allograft coronary artery disease.8 Cardiomyoplasty9 and ventriculectomy10 have generated a great deal of interest in the recent past but their efficacy is largely unproven.
Effect of poly (l-lactic acid) scaffolds seeded with aligned diaphragmatic myoblasts overexpressing connexin-43 on infarct size and ventricular function in sheep with acute coronary occlusion
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Carlos Sebastián Giménez, Fernanda Daniela Olea, Paola Locatelli, Ricardo A. Dewey, Gustavo Abel Abraham, Florencia Montini Ballarin, Maria del Rosario Bauzá, Anna Hnatiuk, Andrea De Lorenzi, Ángela Neira Sepúlveda, Mario Embon, Luis Cuniberti, Alberto Crottogini
Skeletal myoblasts (SkM) are an attractive cell type for cardiomyoplasty as they have a contractile phenotype, can be easily harvested, are resistant to ischemia and secrete cytokines and growth factors involved in cardiac repairing routes [7,8]