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General Anesthetics
Published in Sahab Uddin, Rashid Mamunur, Advances in Neuropharmacology, 2020
Aman Upaganlawar, Abdulla Sherikar, Chandrashekhar Upasani
Despites its very short blood:gas partition coefficient (0.42) and insolubility in fat or other peripheral tissues, produces rapid anesthesia due to 80% rise in the alveolar (and blood) concentration within 5 min (Smiley et al., 1991). With the use of desflurane, the time to awake can be reduced to half time as that of halothane or sevoflurane. A little amount of absorbed desflurane undergoes oxidative metabolism by hepatic CYPs (Koblin et al., 1988).
Orthopaedic Pharmacology
Published in Manoj Ramachandran, Tom Nunn, Basic Orthopaedic Sciences, 2018
Manoj Ramachandran, Daud Chou, Natasha Rahman
Inhalation anaesthetics are volatile liquids or gases that depress the CNS. Rapid induction and recovery are important properties that are determined by the agents solubility in blood (blood: gas partition coefficient) and solubility in fat (lipid solubility).
Interspecies Extrapolation of Toxicological Data
Published in Rhoda G. M. Wang, James B. Knaak, Howard I. Maibach, Health Risk Assessment, 2017
For the inhalation route, the compound is inspired at concentration Cinh with a flow rate equal to the alveolar ventilation rate, Qalv. The model assumes that there is no gas storage in the lungs and that ventilation of the alveoli is continuous, rather than cyclic. The compound in the alveolar air is assumed to equilibrate instantaneously with pulmonary capillary blood so that the compound concentration in lung blood and in alveolar air leaving the lungs maintains a constant ratio specified by the blood/gas partition coefficient, λb.
Comparative Study Between Desflurane and Sevoflurane Regarding Haemodynamics and Recovery Profiles in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy
Published in Egyptian Journal of Anaesthesia, 2023
Sara Mahmoud Afifi Ahmed, Said Mohamed El-Medany Aly, Hesham Ahmed Fouad Shaaban, Kareem Mahmoud Fathi Ateba
Results of the current study demonstrated faster immediate recovery with desflurane compared to sevoflurane. Desflurane’s blood/gas partition coefficient is 30% lower than sevoflurane’s, while its oil/gas partition coefficient is 64% lower, both of which contribute to a faster wash-in and wash-out of desflurane than sevoflurane [13]. Additionally, it is believed that slower recovery following sevoflurane anaesthesia is caused by the prolonged effects of residual sevoflurane (hexafluoroisopropanol) and the fact that sevoflurane breaks down to compound A, which irreversibly binds to body proteins [14]. These observations were similar to studies conducted by La colla et al. [13] and Jindal et al. [15]. In a meta-analysis of non-obese patients, Macario et al. [16] found a similar pattern, noting that the expected advantages of desflurane administration were significantly more prominent in obese patients.
Investigation of health risk assessment sevoflurane on indoor air quality in the operation room in Ahvaz city, Iran
Published in Toxin Reviews, 2019
Abdolkazem Neisi, Masoumeh Albooghobeish, Sahar Geravandi, Hamid Reza Adeli Behrooz, Mohammad Mahboubi, Yusef Omidi Khaniabad, Aliasghar Valipour, Azimeh Karimyan, Mohammad Javad Mohammadi, Majid Farhadi, Ahmad Reza Yari, Ali Ghomeishi
Sevoflurane have health effects for acute exposure. Several study demonstrate the concerning effects of inhalation of volatile AGs especially sevoflurane on human health (Hoerauf et al.1999, Mierdl et al.2003, Summer et al.2003, Gupta et al.2016). Based on report IARC states there are inadequate evidence about various aspects especially the carcinogenicity of sevoflurane, enflurane, halothane and isoflurane in both animals and humans (Kanmura et al.2000, Lachenmeier et al.2009, Kumar and Tripathi 2015). According different study, memory problems, headaches, fatigue, dizziness, impaired fertility, carcinogenesis, decreased immunity, liver and kidney damage are the most important health effects of sevoflurane (Saurel-Cubizolles et al.1992, McGregor 2000, Accorsi et al.2001, Burm 2003, Hasei et al.2003, Michel and Constantin 2009, Tankó et al.2009, Sárkány et al.2016). According result the studied teratogenic, anesthesia gases especially sevoflurane can increase the rate of morbidity on HCWs in ORs (Guirguis et al.1990, McGregor 2000). The blood-gas partition coefficient of sevoflurane is 0.69; molecular weight (200.1); rate of metabolism (3–5%); odor (acceptable); airway irritation (0); recovery (rapid); cost (high) are the most physical properties sevoflurane (Yasuda et al.1991, Michel and Constantin 2009, Devisscher et al.2010, Chatrath et al.2016, Freiermuth et al.2016, Walsh 2016).