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Clinical Progresses in Regenerative Dentistry and Dental Tissue Engineering
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Various sources for postnatal dental stem cells (Simon et al. 2008): Permanent teeth-: Dental Pulp Stem Cells (DPSC): derived from the third molar.Deciduous teeth-: Stem cells from human-exfoliated deciduous teeth (SHED), i.e., stem cell present within the pulp tissue of deciduous teeth.Periodontal ligament-: periodontal ligament stem cells (PDLSCs).Stem Cells from Apical Papilla (SCAP).Stem cells from a supernumerary tooth—mesiodens or stem cells from teeth extracted for orthodontic purposes.Dental Follicle Progenitor Cells (DFPCs) (Vacanti 2006).Stem cells from human Natal Dental Pulp (hNDP).
Removal of unerupted teeth
Published in John Dudley Langdon, Mohan Francis Patel, Robert Andrew Ord, Peter Brennan, Operative Oral and Maxillofacial Surgery, 2017
Catherine Bryant, Clare Gleeson
A supernumerary tooth in the upper labial segment is usually located on the palatal aspect of the permanent incisors, which may remain unerupted because of its presence. These supernumerary teeth in the anterior maxilla can be identified and removed via a flap created by making a gingival crevice incision on the palatal aspect of one or two teeth to each side. It is often possible to raise the flap without disruption to the nasopalatine neurovascular bundle as it emerges from the incisive canal, but if this obstructs the removal of the supernumerary it can be divided to improve access with little consequence. The removal of a high, inverted, often conical supernumerary tooth (a ‘mesiodens’ above and between the roots of the central incisor teeth warrants high-quality imaging, perhaps CBCT, to ensure that this is achieved without excessive bone removal and damage of the adjacent incisor roots, which could result in them becoming non-vital. Although the roots of such supernumerary teeth may lie on the palatal aspect of the incisor roots, their crowns (the widest part) are often superior to the incisor apices and most easily removed with a high buccal approach. It may be possible to elevate the supernumerary tooth intact from the buccal aspect after the overlying bone is removed or if resistance is encountered it can be decoronated and then the root elevated and delivered superiorly (Figure 6.12).
Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development
Published in Organogenesis, 2023
Yuhan Song, Fujie Song, Xuan Xiao, Zhifeng Song, Shangfeng Liu
Tooth development is a dynamic process that includes the bud, cap and bell stages, root development and tooth eruption.9 It is universally known that Wnt signaling pathway plays an important role in tooth development.10 The Wnt signaling molecules are spatiotemporally activated in tooth development, thereby implying its essential role in the process of odontogenesis. The mutations of Wnt signaling genes may result in tooth agenesis (TA). The genetic link between TA and the Wnt pathway was first evidenced by the identification of a mutation of the Axin2 gene in an oligodontia family.10 Mutation of Wnt10a may lead to odonto-onycho-dermal dysplasia, Hypohidrotic ectodermal dysplasia, Schopf-Schulz-Passarge syndrome and many non-syndromic tooth agenesis. Abnormal expression of Wnt10b is related to oligodontia, microdontia, short tooth roots, dental pulp stones, and taurodontism.11–13 Mutation of Lrp6 is also associated with oligodontia, mesiodens, fusion of teeth, odontomas, microdontia, long roots, molars with unseparated roots, and taurodontism. 14,15
Candida biome of severe early childhood caries (S-ECC) and its cariogenic virulence traits
Published in Journal of Oral Microbiology, 2020
Kausar Sadia Fakhruddin, Lakshman Perera Samaranayake, Hiroshi Egusa, Hien Chi Ngo, Chamila Panduwawala, Thenmozhi Venkatachalam, Allagappan Kumarappan, Siripen Pesee
Briefly, dental root-discs obtained from two sound mesiodens and six sound premolars were sterilized using wet-heat under pressure and treated under UV radiation for 3 hours [33]. The teeth were sectioned and placed at the bottom of 12-culture multi-well plates (Corning® Costar® TC-Treated). The structural components of the sectioned teeth comprised mainly of dentine with a marginal layer of cementum.