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Biomedical Microdevices
Published in Sanjay V. Malhotra, B. L. V. Prasad, Jordi Fraxedas, Molecular Materials, 2017
Sharon Y. Wong, Mario Cabodi, Catherine M. Klapperich
An alternative substrate for microfluidic devices is paper. In paper-based microfluidics, the wicking properties of paper are used to drive fluid motion by capillary action. A familiar example of this principle is lateral-flow strips (e.g., home pregnancy tests). While the flow in these strips is one-dimensional, adding micropatterning to the paper substrate (e.g., by printing impermeable barriers) has allowed the creation of more sophisticated two-dimensional fluidic circuits. The printing of such barriers, generally made of wax, lessens concerns about any roughness of the sidewalls—now defined by the resolution of the printing process.
The Basic Concept for Microfluidics-Based Devices
Published in Raju Khan, Chetna Dhand, S. K. Sanghi, Shabi Thankaraj Salammal, A. B. P. Mishra, Advanced Microfluidics-Based Point-of-Care Diagnostics, 2022
Moreover, the white background of paper imparts excellent contrast for colorimetric detection. Owing to the porous nature of paper, paper-based devices have extended applications in the field of filtration and separation. Physical and chemical techniques including inkjet printing, wax patterning, lithography, plasma treatment, and laser treatment are the techniques used in the fabrication of paper-based microfluidics devices. Paper origami and stacking are also techniques that are used to produce 3D paper-based microfluidics devices.
A survey on parameter identification, state estimation and data analytics for lateral flow immunoassay: from systems science perspective
Published in International Journal of Systems Science, 2022
Han Li, Peishu Wu, Nianyin Zeng, Yurong Liu, Fuad E. Alsaadi
Aiming at the capillary-driven flow, kinetics of capturing the analyte is modelled in Berli and Kler (2016), where a simple model based on algebraic expressions is proposed. The particle transport and immunoreactions while flowing over a porous membrane are all formulated, and governing factors in LFIA are condensed into two dimensionless numbers, which can characterise the complete system. More importantly, this model can also provide an in-depth comprehension of the physicochemical process in other paper-based microfluidics. In particular, simulation results indicate that based on proposed model, questions of several fundamental configurations such as flow rate and analyte concentration can be well answered, which benefits LFIA optimisation with reliable theoretical supports.