Single particle analysis

Single particle analysis refers to a technique used to determine the compositional and physical characteristics of individual particles. This method allows for the detection of small elements that are localized within each particle. Unlike other analysis techniques, such as PTA or quantitative-TEM, single particle analysis accurately measures each individual particle.From: Particle Control for Semiconductor Manufacturing [2018], Tribo-mechanical performance of brake composite material: a comprehensive review [2023], Characterisation of particles in solution – a perspective on light scattering and comparative technologies [2018]

Particle Identification

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Purchase Book

Published in R. P. Donovan, Particle Control for Semiconductor Manufacturing, 2018

Wayne G. Fisher, Jeffrey M. Davidson

Two general types of analyses can be applied to particles: (1) single particle analysis, and (2) bulk analysis. In single particle analysis, the compositional and physical characteristics of each individual particle are determined. Bulk analysis averages out the compositions of all particles obtained in a sample and is generally incapable of determining physical characteristics of particles.

Characterisation of particles in solution – a perspective on light scattering and comparative technologies

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Journal Information

Published in Science and Technology of Advanced Materials, 2018

Ciarán Manus Maguire, Matthias Rösslein, Peter Wick, Adriele Prina-Mello

As previously stated, DLS is an average-based technique, with the Z-average diameter representing the light scattering intensity average of the sample. In contrast, single-particle analysis techniques, such as PTA, or single-particle inductively coupled plasma mass spectrometry or quantitative-TEM accurately measure individual particle. These single particle, or analyte, techniques are becoming increasingly utilised in a number of other analytical areas, with techniques such as single-cell mRNA sequencing operating under a similar principle, compared to the ensemble measurements via bulk RNA sequencing [26,27], since they allow for the analysis of the true variability within a sample or population.

Single particle analysis

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Particle Identification

Characterisation of particles in solution – a perspective on light scattering and comparative technologies