Wittig reaction

Wittig reaction

Organic Synthesis

Published in Suresh C. Ameta, Rakshit Ameta, Garima Ameta, Sonochemistry, 2018

Chetna Ameta, Arpit Kumar Pathak, P. B. Punjabi

Wittig reaction or Wittig olefination is a chemical reaction of an aldehyde or ketone with a triphenyl phosphonium to give an alkene and triphe- nylphosphine oxide. This reaction was discovered by Georg Wittig (Wittig and Schollkopf, 1954). These reactions are most commonly used to couple aldehydes and ketones to singly substituted phosphine ylides with unstabilized ylides. This results in almost exclusively the Z-alkene product (Wittig and Haag, 1955).

A review on DBU-mediated organic transformations

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Journal Information

Published in Green Chemistry Letters and Reviews, 2022

Shashi Kanth Boddu, Najeeb Ur Rehman, Tapan Kumar Mohanta, Anjoy Majhi, Satya Kumar Avula, Ahmed Al-Harrasi

The Horner-Wadsworth-Emmons reaction, a modification of the Wittig reaction has been employed frequently for the synthesis of α,β-unsaturated esters. Ando et al. efficiently developed the solvent-free Horner-Wadsworth-Emmons reaction with a variety of aldehydes in the presence of DBU to give E-α,β-unsaturated esters and ketones in high yields. The E-selectivity of the product was high and the used DBU catalyst was recovered (Scheme 40) (56,57).

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Organic Synthesis

A review on DBU-mediated organic transformations