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19F
Published in Guillaume Madelin, X-Nuclei Magnetic Resonance Imaging, 2022
Lanza et al. [86] encapsulated antiproliferative agents such as doxorubicin and paclitaxel into a PFOB nanoemulsion and delivered the tracer directly into the vascular walls, allowing monitoring and quantitative analysis of the delivery with 19F MRI. 19F MRS has been used in pharmacokinetic studies of the anticancer antineoplastic agent drug 5-FU, which can be applied in concomitant radiotherapy and chemotherapy of different neoplastic diseases, such as cancer of the colorectal system, the head and neck, the trunk and some breast cancers [5, 87–91]. Because of the intrinsic toxicity of 5-FU, different pro-drugs (a drug in its non-active form) of the molecule have been designed to pass intact through the gastrointestinal tract, which then ultimately can localize and selectively convert to active 5-FU in the malignant tissue, based on the higher activity of thymidine phosphorylase [92, 93].
Biocatalytic Nanoreactors for Medical Purposes
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2019
Oscar González-Davis, Chauhan Kanchan, Rafael Vazquez-Duhalt
Mitochondrial neurogastrointestinal encephalomyopathy is a progressive metabolic disorder caused by thymidine phosphorylase enzyme deficiency. Clinical features include mental regression, ophthalmoplegia, and fatal gastrointestinal complications (Yadak et al., 2017). Thymidine phosphorylase was encapsulated into polymeric NPs (De Vocht et al., 2009) and erythrocytes (Moran et al., 2008) in order to prolong half-life and reduce the immunogenic reactions.
A catalytic regioselective procedure for the synthesis of aryl oximes in the presence of palladium nanoparticles
Published in Inorganic and Nano-Metal Chemistry, 2022
Emine Demir, Ersin Orhan, Haydar Goksu
For example, oxiconazole,[5] aztreonam,[6] and fenpyroximate[7] contain the oxime skeleton and are compounds with proven antifungal, antibacterial, and antitumor effects, respectively (Scheme 1). Moreover, p-methoxy benzyl oxime and 1-(aryl aldehyde oxime) uracil derivatives inhibit MRCK kinase[8] and thymidine phosphorylase (TP),[9] respectively, which are responsible for the spread of cancer cells. Of course, although oxime compounds exhibit all these activities, the effect of the stereoisomeric structures should not be ignored.