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Published in Maurizio Cumo, Antonio Naviglio, Safety Design Criteria for Industrial Plants, 2019
Claudia Bartolomei, Sergio Paribelli
Special precautions and preventive measures — Liquid propylenimine will attack some forms of plastics, rubber, and coatings. Wear impervious clothing, gloves, face shields (8 in. minimum), and other appropriate protective clothing necessary to prevent skin contact with liquid propylene imine.
Dendrimer as a promising nanocarrier for the delivery of doxorubicin as an anticancer therapeutics
Published in Journal of Biomaterials Science, Polymer Edition, 2021
Vanshikha Singh, Prashant Kesharwani
PPI was the first dendrimer developed by Buhleier et al. It consists of primary amines as terminal group, tertiary tris propylene amino group inside the polypropylene imine structure. Like PAMAM, they are one of the most widely studied class of dendrimers. In these dendrimers, 1,4-diaminobutane (DAB) or diaminoethane are the core structure but they can also be synthesized from other core molecules via double Michael addition reaction [66–69]. In comparison to PAMAM, PPI have a more hydrophobic interior contributed by the presence of alkyl chains in their branching. PPI can be alternatively termed POPAM which utilizes poly propylene amine [70,71]. Various dendrimers are being studied based on conjugation of PPI and drug. Some of which includes melphalan-loaded folate-conjugated poly(propyleneimine) dendrimer (FPPI) [57], DOX–PPI conjugate dendrimer linked with DOX, and dextran and Folate-modified PPI G5 dendrimer loaded with methotrexate.
Conducting an evaluation of CBRN canister protection capabilities against emerging chemical and radiological hazards
Published in Journal of Occupational and Environmental Hygiene, 2020
Lee A. Greenawald, Christopher J. Karwacki, Frank Palya, Matthew A. Browe, David Bradley, Jonathan V. Szalajda
Five hazards could not be categorized into NIOSH’s Chemical Families based on the current NIOSH criteria for each family: (1) carbon monoxide; (2) propylene oxide; (3) ethyleneimine (aziridine); (4) propyleneimine; and (5) hydrogen selenide. These hazards could not be assigned to a current chemical family due either to physical/chemical properties outside the range of properties determined for each family, or their chemical properties or filtration properties were not well understood. These chemicals are expected to have limited capacity for physical adsorption due to their very high vapor pressures and may be filtered out by chemisorption with metal oxides. These chemicals require filter laboratory testing under various conditions to better understand whether they can be properly grouped into one of the existing chemical families. Carbon monoxide is generally not removed by activated carbon and requires chemisorption/chemical reaction mechanisms (Dey et al. 2017). Due to resources available within this study, laboratory testing has not yet been conducted for these five chemicals. If they can be grouped into an existing NIOSH Chemical Family, collecting empirical filtration data will determine if the existing TRA(s) are accurately representative. If any of the five chemicals cannot be grouped into current NIOSH Chemical Families, one or more additional Chemical Families may be needed.