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Terpenoids Against Infectious Diseases
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Sanhita Ghosh, Kamalika Roy, Chiranjib Pal
Baseline characteristics, including the frequency of methicillin-resistant Staphylococcus aureus (MRSA), were comparable between the different treatment groups. Amongst 210 treated patients, 186 (88.6%) patients completed the study. Clinical success at TOC in the clinically evaluable population occurred in 54 (90.0%) patients in the BC-3781 100 mg group, 48 (88.9%) in the BC-3781 150 mg group and 47 (92.2%) in the Vancomycin group. At Day 3, the clinical response rate was similar across the three treatment groups. The incidence rate for drug-related adverse events was lower for patients receiving BC-3781 (34.3% and 39.4% in the 100- and 150-mg groups, respectively) than those receiving Vancomycin (53.0%). BC-3781 was generally well tolerated. These results provided the first proof of concept for the systemic use of a Pleuromutilin antibiotic for the treatment of ABSSSI (Prince et al. 2013).
Improvement of biotreatability of environmentally persistent antibiotic Tiamulin by O3 and O3/H2O2 oxidation processes
Published in Environmental Technology, 2022
Andreja Žgajnar Gotvajn, Ján Derco, Martin Vrabeľ, Angelika Kassai
Tiamulin has been widely applied in China for prophylaxis of dysentery and pneumonia, primarily in pigs and poultry. It was detected in swine manure samples (43 μg kg−1) in Germany [10]. Berendsen et al. [11] assessed the persistence of a broad range of antibiotics during calve, pig and broiler manure storage, determining the DT90 time (time for 90% of the initial compound degradation). DT90 time for Pleuromutilin group is between 49 and 1100 days – Tiamulin specifically was found to be one of the most persistent molecules, with degradation time independent of the type of the manure.