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Significance of Industry 5.0
Published in Pau Loke Show, Kit Wayne Chew, Tau Chuan Ling, The Prospect of Industry 5.0 in Biomanufacturing, 2021
Yoong Kit Leong, Jian Hong Tan, Kit Wayne Chew, Pau Loke Show
The pharmaceutical industry will also be revolutionized by Industry 5.0 mostly, in drug design and discovery through AI and machine learning. Currently, the medical and pharmaceutical practices drug design and development from scratch, which has multiple cumbersome stages. Pharmaceutical drugs are commonly used at a standard, where the mechanism of action along with possible side-effects differ for different persons. Also, there is difference in the dosage of drug, which is dependent on the individual patient’s circumstances and requirements. There are a lot of variables when it comes to the efficacy of drugs and medicines as they can be affected by an individual’s health and fitness, lifestyle choices, genetic makeup and even sex. Medicine that is effective for one person may be less effective for another highlights the importance of personalized medicine (Fröhlich et al. 2018). The pharmaceutical industry would be so much safer with AI-supported pharmacovigilance, which has less human errors to overlook drug developments (λ).
Future of Parenteral Manufacturing
Published in Sandeep Nema, John D. Ludwig, Parenteral Medications, 2019
James Agalloco, James Akers, Russell Madsen
The pharmaceutical industry is highly regulated, primarily by agencies such as FDA (United States), EMA (Europe), and MHLW (Japan).* These agencies seek to ensure the safety and efficacy of pharmaceuticals by means of registration requirements and inspections designed to ensure that the manufactured products comply with the standards contained in their approved applications and that appropriate manufacturing controls required by the various Current Good Manufacturing Practice (CGMP) regulations are in place. The industry must also concern itself with pharmacopeial standards contained in the USP, JP, and Ph. Eur.† Also, compliance with other regulations such as environmental and employee safety and health remains.
Pharmaceuticals
Published in James G. Speight, Handbook of Petrochemical Processes, 2019
The pharmaceutical industry includes the manufacture, extraction, processing, purification, and packaging of chemical materials to be used as medications for humans or animals. Pharmaceutical manufacturing is divided into two major stages: (i) the production of the active ingredient or drug (primary processing, or manufacture) and (ii) secondary processing, the conversion of the active medicines into products suitable for administration. However, before a medication can be manufactured at any scale, much work goes into the actual formulation of the medicine. Formulation development scientists must evaluate a compound for uniformity, stability, and many other factors. After the evaluation phase, a solution must be developed to deliver the medication in its required form such as solid, semisolid, immediate or controlled release, tablet, and capsule.
Blockchain implementation in pharmaceutical supply chains: A review and conceptual framework
Published in International Journal of Production Research, 2023
Abhijeet Ghadge, Michael Bourlakis, Sachin Kamble, Stefan Seuring
The pharmaceutical industry is strictly supervised by government departments such as the FDA and FMD (Falsified Medication Directive) and other non-profit organisations like WHO. Organisations are required to follow the regulations and combat counterfeited products. Developed countries are taking more practical actions in detecting falsified drugs than developing countries. The pilot projects on Blockchain, such as MediLedger and PharmaLedger, are designed to collaborate with global pharmaceutical manufacturers, distributors, hospitals, and pharmacies to make transactions on the distributed ledger. Similarly, the European Federation of Pharmaceutical Industries and Associations (EFPIA) is also focused on detecting counterfeited products in the PSC and are trying to eliminate unqualified drugs. The NHS (National Health Service, United Kingdom) follows the FMD directives and brings pharmacies together to supervise this medication movement. Developing countries like India and Brazil also promote Blockchain projects to improve their healthcare service level (Dhagarra et al. 2019). Stakeholder’s pressure
Coalitional strategies of the pharmaceutical supply chain with an option contract to cope with disruption risks
Published in International Journal of Logistics Research and Applications, 2022
Xinhua He, Wenjun Liu, Wenfa Hu, Xianhua Wu
The pharmaceutical industry plays an indispensable role in modern society and its economic development (Serrano 2019). The COVID-19 pandemic evolves into the biggest health crisis in the twenty-first century and the pharmaceutical industry is facing unforeseen challenges, and even the pharmaceutical process systems in developed countries are overwhelmed by the epidemic (Yu, Razon, and Tan 2020). The pharmaceutical process capability is to measure the capability that a PSC delivers pharmaceutical products to customers without interruption, which depends on complicated cooperation among participants and pharmaceutical quality monitoring. when confronting a public health emergency, the PSC should maintain its process capability, which is also its social responsibility.
Pharmaceutical quality control laboratory digital twin – A novel governance model for resource planning and scheduling
Published in International Journal of Production Research, 2020
Miguel R. Lopes, Andrea Costigliola, Rui Pinto, Susana Vieira, Joao M.C. Sousa
The pharmaceutical industry is an intricate conglomerate of organisations partaking in the research, development, manufacturing, distribution and retail of medicinal drugs. The underpinning complex processes and operations of the aforementioned practices take place along a world-wide network of R&D centres, factories, distribution hubs and retailers, through which raw materials are acquired, synthesised into drugs and made available to customers – within a framework akin to that of a modern, integrated Supply Chain (SC), as described by Surana et al. (2005).