Interstitial collagenase

Interstitial collagenase, also known as MMP-1, is an enzyme that breaks down collagen in the extracellular matrix of tissues, particularly in the interstitial spaces between cells. It is also referred to as fibroblast collagenase due to its ability to degrade collagen produced by fibroblasts.From: Encyclopedia of Biomaterials and Biomedical Engineering [2019], Culture of pyramidal neural precursors, neural stem cells, and fibroblasts on various biomaterials [2018]

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Exploring Nanoformulations of Pomegranate as Promising Nutraceuticals

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Published in Bhupinder Singh, Minna Hakkarainen, Kamalinder K. Singh, NanoNutraceuticals, 2019

Surbhi Dhawan, Sanju Nanda, Supriya Verma, Pradip Nirbhavane, Bhupinder Singh

The peel of fruit is well-regarded for its astringent properties, as well as for its impressive antioxidant and antimicrobial potential. The aqueous peel extract of pomegranate is a potential source of antibacterial, antifungal, and antioxidant agents and could be used as a natural antioxidant and preservative in food and nonfood systems. It also exhibits good reducing power and iron-chelation capacity. Pomegranate peel extract possesses a strong potential for development as an anti-carcinogenic, antioxidant, and anti-inflammatory agent. Pomegranate peel extract could be used in preventing the incidence of long-term complication of diabetes (Ahmed et al., 2014; Barathikannan et al., 2016; Saffarzadeh-Matin et al., 2017). Pomegranate peel extract, and to a lesser extent its fermented juice and seed cake extracts, stimulated type I procollagen synthesis and inhibited matrix metalloproteinase-1 (interstitial collagenase) production by dermal fibroblasts, but had no growth-supporting effect on keratinocytes. These results suggest heuristic potential of pomegranate fractions for facilitating skin repair in a polar manner, with the aqueous extracts (especially of pomegranate peel) promoting regeneration of dermis.

Culture of pyramidal neural precursors, neural stem cells, and fibroblasts on various biomaterials

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Published in Journal of Biomaterials Science, Polymer Edition, 2018

Mo Li, Ying Wang, Jidi Zhang, Zheng Cao, Shuo Wang, Wei Zheng, Qian Li, Tianqi Zheng, Xiumei Wang, Qunyuan Xu, Zhiguo Chen

Addition of a larger number of pyramidal neurons resulted in accelerated degradation of fibrin. To learn more about how the cells may have affected the materials, we examined the expression of different matrix metalloproteinases (MMP) from these cells. Expression of MT4-MMP, MMP1 and MMP10 were analysed. The substrates of MMP-MT4 include fibrinogen and fibrin. MMP1 was known as interstitial collagenase and fibroblast collagenase. MMP10 degrades proteoglycans and fibronectin.