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Hemolytic Assay of Biocompatible Nanomaterials in Drug Delivery Systems
Published in Ali Pourhashemi, Sankar Chandra Deka, A. K. Haghi, Research Methods and Applications in Chemical and Biological Engineering, 2019
Poonam Khullar, Lavanya Tandon, Rajpreet Kaur, Divya Mandial
Indocyanine green (ICG) is a fluorescence dye which is used for near-infrared imaging. There is a limited application of this dye due to its various disadvantageous properties in aqueous solution, which also includes concentration-dependent aggregation, poor aqueous stability in vitro and low quantum yield. ICG is highly bound to nonspecific plasma proteins, which leads to rapid elimination from the body with a half-life of 3–4 min. ICG was made to encapsulate within various micellar systems so as to overcome these limitations. The micellar systems have been characterized by their optical properties, particle size distribution, zeta potential, and hemolytic activity. Encapsulation efficiency was determined using analytical ultracentrifugation.
Indocyanine green-loaded exosomes for image-guided glioma nano-therapy
Published in Journal of Experimental Nanoscience, 2022
Bo Fan, Song Yang, Yuan-yu Wang, Chao Zhang, Ji-peng Yang, Li-qun Wang, Zhong-qiang Lv, Xue-fang Shi, Zhen-zeng Fan, Jian-kai Yang
Indocyanine green (ICG) is a clinical near-infrared fluorescent dye that has high active oxygen quantum yield under the induction of near-infrared laser. It not only has strong photodynamic performance, but also has certain photothermal performance. Therefore, it can be used for photodynamic therapy of tumors and auxiliary photothermal therapy. Previous study discovered that tumors absorb more ICG than other tissues, as evidenced by 2.5 times the light responses of tumor than neighboring tissues when ICG was injected near tumor [15]. However, due to its unstable property in a liquid environment, ICG can be easily cleared in the blood circulation, contributing to lack of targeting, which results in insufficient bioavailability at tumor sites and limiting its application in cancer therapy. Therefore, our current study aimed to develop a new carrier for ICG to direct target brain tumor for the improvement of GBM treatment.
Enhancement in the Vision of Branch Retinal Artery Occluded Images Using Boosted Anisotropic Diffusion Filter – An Ophthalmic Assessment
Published in IETE Journal of Research, 2022
S.G. Gayathri, S. Joseph Jawhar
Retinal imaging in ophthalmology includes Color fundus photography. Specially designed cameras are used to acquire photographs of the ocular fundus. In recent years, fundus cameras has been most widely used for image acquisition and have transformed from film to digital image. Fundus Fluorescein Angiography (FFA) is another type of imaging in ophthalmology which injects dye and then by using reflection of white light occurs funds photos. Another similar imaging technique as FFA is indocyanine green angiography (ICG). Commonly used funds cameras are Topcon TRC-50DX (Topcon) and the Zeiss FF450plus (Zeiss) which is mostly preferred for their optical field of view, with most commonly used angle (30° or 35°). Acquiring color photographs of the retina has become usefull for all hospital eye services. Thus color fundus photography plays an essential role in diagnosis and assessment of most peculier ocular diseases as well as for disease viewing. It is also commonly used in ophthalmic clinical trials and epidemiological studies. Figure 2 shows the retina image captured using Zeiss FF 450 Plus.
Use of XyCAM RI for Noninvasive Visualization and Analysis of Retinal Blood Flow Dynamics During Clinical Investigations
Published in Expert Review of Medical Devices, 2021
Delia Cabrera DeBuc, Abhishek Rege, William E. Smiddy
Moreover, while much has been learned, there is an incomplete understanding of the pathogenesis of diseases such as glaucoma and AMD. Current therapeutics, generally, can only retard the progression of disease, so detection at an earlier stage may offer a marked improvement in outcomes [1,19]. However, about one-tenth of the glaucoma patients who undergo treatment would still experience some vision loss. In order to obtain a deeper understanding of pathogenesis of these diseases, it is important to visualize and assess blood flow dynamics and its role in development of these diseases[3]. Most standard clinical ophthalmic diagnostic technologies like OCT and fundus imaging can image and assess the structural information of the eye but do not provide functional information. While dye-based technologies like fluorescein angiography (FA) and indocyanine green angiography (ICGA) can provide insights into blood flow in the eye, they cannot quantify the same and their application is limited by the associated complexities, effort, patient discomfort, and risk of side-effects. Hence, there is a strong unmet need for an ophthalmic imaging technology, which is easy-to-use in regular clinical settings, is noninvasive, and provides blood flow visualization and assessment capabilities. To summarize, a noninvasive technology for visualization and assessment of OBF and dynamics could make a significant difference in being able to address global eye health challenges due to diseases such as AMD, glaucoma, DR, and other retinal vascular abnormalities.