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Research, Development, and Innovation in Dairy and Meat-Based Foods Using Valued Added Compound Obtained from Mediterranean Fruit By-Products
Published in Francisco J. Barba, Elena Roselló-Soto, Mladen Brnčić, Jose M. Lorenzo, Green Extraction and Valorization of By-Products from Food Processing, 2019
José Angel Pérez-Alvarez, Manuel Viuda-Martos, Juana Fernández-López
Citrus fruit and juices represent one of the main sources of compounds with high health-promoting properties. Fresh lime by-products contained significant amounts of vitamin C, phenolic compounds, and flavonoids (Jongaroontaprangsee et al., 2014). Hesperidin was a major flavonoid, and only one polymethoxyflavone (tangeretin) was detected in small amounts in oranges. Omar et al. (2016) mentioned that hesperidin, a naturally occurring flavonoid, exerts many clinically appreciable effects, including antioxidant, anti-allergic, and anti-inflammatory actions. As regards hesperidin, Li and Schluesener (2017) mentioned that this flavanone (also its aglycone hesperetin) has pharmacological activities and widespread application in diseases, such as neurological disorders, psychiatric disorders, and cardiovascular diseases and others, due to its anti-inflammatory, antioxidant, lipid-lowering, and insulin-sensitizing properties. Barreca et al. (2017) reported that citrus bioactive compounds (hesperetin, naringenin, eriodictyol, isosakuranetin, and their respective glycosides) also enhance the body’s defenses against oxidative stress.
Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan
Hesperidin, commonly found in the citrus family, is of greater pharmacological significance as a powerful anti-inflammatory and anti-diabetic bioactive. It is a commonly available drug across the world used for treating vascular dilation (Haggag et al. 2020). In COVID-19 research, hesperidin helps in triggering the host immune system and acts as an antiviral bioactive in other respiratory-related viral infections. Hesperidin, customarily used in Chinese traditional medicine, is also shown to display antitumour effects against a broad spectrum of tumours, especially breast cancer, by downregulating few genes in signalling pathways necessary for cancer cell growth, multiplication, and metastasis (Kongtawelert et al. 2020).
Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, Sarwar Beg
Hesperidin is a citrus flavonoid reported for its wide variety of pharmacological effects. The therapeutic effect of hesperidin is well investigated in the adjuvant rat arthritis model. At the 80, 160 mg/kg dose of hesperidin inhibits significantly the secondary paw swelling and down regulates production of IL-1, IL-6, and TNF-a in RA rats. Another research has shown that hesperidin has a significant impact of suppressing synoviocytes’ proliferation in rat adjuvant arthritis model.
Hesperidin augments the health beneficial effects of alternate day fasting in male rats
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Sukanya Bhoumik, Rashmi Kesherwani, Raushan Kumar, Syed Ibrahim Rizvi
Hesperidin is a citrus antioxidant having protective properties against oxidative stress-induced damage [14]. The present study was undertaken to assess the effect of hesperidin administration on oxidative biomarkers in rats under ADF regimen. Hesperidin shares some common protective pathways with ADF. The role of hesperidin as an antioxidant is to provide protection against oxidative stress by upregulating the expression of Nrf2 gene, whereas ADF also mitigates oxidative damage and increases longevity by activating pathways induced by Nrf2 which corresponds to stress resistance in response to oxidative stress [14]. Therefore, our results provide an overview of the synergistic benefits observed during antioxidant supplementation in rats which were maintained on a dietary restriction regimen.
Effects of hesperidin on anti-inflammatory and antioxidant response in healthy people: a meta-analysis and meta-regression
Published in International Journal of Environmental Health Research, 2022
Yusuf Buzdağlı, Cemre Didem Eyipınar, Fatma Necmiye Kacı, Aslıhan Tekin
To overcome all these problems and cope with metabolic events such as oxidative stress and inflammation, treatments today have directed people to consume natural products. Citrus flavanones such as hesperidin, naringin, narutin, poncirin, and eriocitrin, are the most helpful and potential anti-inflammatory and antioxidant bioactive ingredients (Gattuso et al. 2007; Tripoli et al. 2007; Wang et al. 2017). Among them, hesperidin is plentiful in the peel of citrus fruits, especially oranges and it is now widely recognized for its health-promoting properties (Ganeshpurkar and Saluja 2019). The anti-inflammatory properties of hesperidin and other flavonoid compounds are explained by the following four basic mechanisms: i) antioxidant and free radical scavenging effect, ii) inhibition of pro-inflammatory enzymes, iii) modulation of pro-inflammatory mediators, iv) modulation of pro-inflammatory gene expression regulators (Silva et al. 2021). In the literature, the antioxidant properties of flavonoids are generally considered as the subtitle of their anti-inflammatory properties.