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Chemicals from Aromatic Hydrocarbons
Published in James G. Speight, Handbook of Petrochemical Processes, 2019
The Grignard reaction is an organometallic chemical reaction in which alkyl, vinyl, or aromatic magnesium halide will add to a carbonyl group (>C=O) in an aldehyde or ketone (Figure 8.2). Thus:
Interfacial properties of sodium para-dimethyl alkylbenzene sulfonate in the presence of monovalent metal counterions at the oil-water interface
Published in Journal of Dispersion Science and Technology, 2020
Yulian Jiang, Changming Zhao, Yue Wang, Tiexin Cheng, Guangdong Zhou
The p-S14-4 was prepared via Friedel–Crafts acylation, Grignard reaction, hydrogenation reduction, sulfonation and neutralization with butyryl chloride, p-xylene and n-bromodecane as starting materials.[25] The synthesis flowchart is drawn in Figure 2. There are some key steps to be taken into consideration, such as the control of the proportion of raw materials and the temperature in the process of Friedel–Crafts acylation, the preparation of Grignard reagent and the Grignard reaction under the protection of nitrogen, the control of experimental conditions in the process of hydrogenation reduction and the treatment of crude products after sulfonation and so on, and the more detailed synthesis steps stem from a literature.[25]
Iodination of vanillin and subsequent Suzuki-Miyaura coupling: two-step synthetic sequence teaching green chemistry principles
Published in Green Chemistry Letters and Reviews, 2019
James J. Palesch, Beau C. Gilles, Jared Chycota, Moriana K. Haj, Grant W. Fahnhorst, Jane E. Wissinger
Continuing with our efforts to revise the organic chemistry laboratory curriculum to demonstrate modern green synthetic methods, we sought to replace our program’s decades-old electrophilic aromatic substitution (EAS) reaction and Grignard synthesis with more environmentally-friendly chemistries. These classes of reactions are important topics to include in both organic chemistry lecture and laboratory courses. EAS reactions are invaluable synthetic tools for functionalizing aromatic compounds, and the Grignard reaction has historically been a primary carbon–carbon bond forming reaction. Though there are reported green replacements for each of these types of reactions (1), we sought to develop novel experiments which would complement our current curriculum with specific learning outcomes related to guided-inquiry pedagogy, spectroscopic analysis, laboratory techniques used, green chemistry principles, and scalability for the large teaching laboratory environment.
Identification of diluent degradation products in radiolyzed PUREX solvent
Published in Solvent Extraction and Ion Exchange, 2018
Satyabrata Mishra, Anil Kumar Soda, Madabhushi Sridhar, C Mallika, N. K Pandey, U. Kamachi Mudali
Six regioisomers are possible for dodecanol. Nevertheless, only three of them were present as a mixture in F2. Since 13C NMR spectral data of the isomers (dodecan-3-ol, dodecan-4-ol and dodecan-5-ol) are not available in literature, those compounds were synthesized by Grignard reaction using the corresponding aldehyde and alkyl bromide in the author’s laboratory (dodecan-1-ol and dodecan-2-ol were obtained commercially) and the individual 13C NMR spectra recorded for the five dodecanol isomers (reproduced in the supplementary data file) were compared with the 13C NMR spectrum obtained for F2.