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Toxicity of Terpenoids in Human Health
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Ritobrata Goswami, Dijendra Nath Roy
Eucalyptol, a colourless organic compound, is a monoterpenoid and an ether. Among its various uses, eucalyptol is predominantly used as an insecticide and in fragrances (Klocke et al. 1987). The question of whether eucalyptol could potentiate toxicity has been assessed because of its widespread use in households. When Kunming mice received feed with a high dose of eucalyptol, liver and kidney tissue demonstrated vacuolar and granular degeneration (Xu et al. 2014). When the animals were fed with a subacute dose of eucalyptol, no discernible difference in body weight was observed (Xu et al. 2014). Eucalyptol’s safety profile has been assessed. Fatality after ingestion of eucalyptol oil has been reported; the approximate lethal dose of eucalyptol in the human is between 0.05 and 0.5 mL/kg of body weight (Hindle 1994). When male rats received eucalyptol, eosinophilic protein droplets accumulated in a dose-dependent fashion (Kristiansen and Madsen 1995). However, in a study of mutagenicity using CHO cells, eucalyptol did not induce mutagenicity as evidenced in the sister chromatid exchange assay (Galloway et al. 1987). Likewise, eucalyptol did not induce carcinogenicity in pathogen-free CFLP mice (Roe et al. 1979).
Synthesis of natural nanopesticides with the origin of Eucalyptus globulus extract for pest control
Published in Green Chemistry Letters and Reviews, 2019
Zohreh Khoshraftar, Ali Akbar Safekordi, Ali Shamel, Mohammad Zaefizadeh
The characterization of chemical compounds in the hydroalcoholic Eucalyptus globulus extract is shown in Table 2. The major chemical compounds in the hydroalcoholic extract were found (Table 2) as 1,8-cineole (70.94%), 3-cyclohexene-1-ol (3.13%), beta. fenchyl (5.38%), 1,2-benzenedicarboxylic acid (6.08%), dodecane (1.50%). Eucalyptol (1, 3, 3-trimethyl-2-oxabicyclo [2.2.2] octane), also known as 1,8-cineole (CIN), is a natural constituent of the several natural sources (45, 46). The main source is the Eucalyptus leaf oil, where CIN is present up to 90% (47). The 1,8-cineole content of Eucalyptus globulus oil reported in the literature was 32.62%. This wide variation in chemical composition of Eucalyptus globulus could be ascribed to environmental conditions (48). Several studies have been undertaken in the past to discover the potential of plants. 1,8-cineole, on the other hand, exhibits insecticidal activity 1,8-cineole, on the other hand, exhibits insecticides activity (27, 49–51).