Diketones

Diketones

A diketone is an organic molecule that contains two keto groups separated by one methylene group (>CH2). The simplest example of a diketone is diacetyl. Diketones are building blocks of many natural compounds such as pheromones or anti-tumor agents, whereas ketones with an aromatic side chain are used in a wide field of medicinal applications.From: Chemical Processing of Ceramics [2019], Elastic and Plastic Deformation of Carbon Nanotubes [2019], Pharmaceutical Biocatalysis [2019]

Rhodococcus Alcohol Dehydrogenases

View Chapter

Purchase Book

Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2019

Marion Rauter, Simon Krebs, Gotthard Kunze

Ketoesters as α- and β-ketoesters are reduced to α- and β-hydroxyesters, which are important intermediates for many complex substances. Those motifs can be found in a variety of natural products, such as statin side chains, prostaglandins or leukotrienes. Diketones are building blocks of many natural compounds such as pheromones or anti-tumor agents, whereas ketones with an aromatic side chain are used in a wide field of medicinal applications. Numerous substances contain halogenated side-chains of which α-halo ketones are from special interest. Their corresponding halohydrins are versatile intermediates for the synthesis of biologically active compounds as potent protease inhibitors employed against HIV. Fluorinated substances make approximately 20% of all available drugs. The application of heterocyclic chiral alcohols is as diverse as their structure. Some of them are used as intermediates for central nervous system modulators or as therapeutic agents against cocaine abuse (Cuetos et al., 2014).

A review on DBU-mediated organic transformations

View Article

Journal Information

Published in Green Chemistry Letters and Reviews, 2022

Shashi Kanth Boddu, Najeeb Ur Rehman, Tapan Kumar Mohanta, Anjoy Majhi, Satya Kumar Avula, Ahmed Al-Harrasi

An efficient and simple one-pot procedure for the synthesis of α-diketones from a variety of aldehydes via benzoin condensation under the influence of a catalytic amount of DBU-NHC has been developed by Shimakawa et al. (Scheme 58) (75).

Explore chapters and articles related to this topic

Rhodococcus Alcohol Dehydrogenases

A review on DBU-mediated organic transformations