China
Africa
Explore chapters and articles related to this topic
Medication: Nanoparticles for Imaging and Drug Delivery
Published in Harry F. Tibbals, Medical Nanotechnology and Nanomedicine, 2017
Drugs and proteins have been conjugated with special types of polymers. Dendrimers and dendronized polymers, with their well-defined monodisperse structures, are being explored for improved precision of therapy delivery over heterogeneous, random-coiled, polymeric carriers. Dendrimers, dendronized polymers, stars, hyperbranched polymers, and similar polymer structures can be synthesized with monodisperse nanoscale geometries and high functional group density. Dendrimers, with multiple sites for ligands on their outer surfaces, offer an especially attractive vector for targeting folate receptors, P2Y14 receptors, and other G-protein-coupled receptors [160-164]. Other interesting polymer architectures being explored include chimeric block copolymers with amino acid sequences in the polymer, and other hybrid glyco- and peptide-derivatives [165,166].
Polymers in Special Uses
Published in Manas Chanda, Plastics Technology Handbook, 2017
Dendronized polymers, i.e., polymers with dendritic side chains, are currently under intense investi-gation with respect to various applications, including the synthesis of hierarchically structured materials, catalysis, applications in the biosciences, such as ion channel mimics and DNA compactization, as well as photoelectronics applications [222].
Recent advancements and perspective of ciprofloxacin-based antimicrobial polymers
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Shreya Kanth, Yashoda Malgar Puttaiahgowda, Sonali Gupta, Swathi T.
Bioadhesive films were prepared using new derivate biomaterials based on weisocyanate-dendronized polyvinylpyrrolidone-crosslinked chitosan and filled with CPF, a model antibiotic by Garcia et al. [65]. A two-step synthesis was used to create the dendronized polymer: Ch film and one-side dendronization (ChW) and further loaded with CPF (Ch-CPF and ChW-CPF) [114]. The distinctive properties such as non-toxicity, biodegradability, antibacterial activity, and biocompatibility of chitosan were all preserved in the dendronized films. Further, the drug-delivery profile and physic-chemical characteristics of the films were controlled by dendronization. Throughout the films, the CPF was found to be distributed uniformly. The antibacterial activities of both films were examined against P. aeruginosa and S. aureus. It was found that the zone of inhibition exhibited was proportional to the concentration of CPF in the film and Ch-CPF showed better activity than ChW-CPF against the tested microbes. When the film comes into contact with the agar, CPF is released and diffuses, preventing microbiological growth. The type of receptor media and dendronization influenced the controlled release of CPF. Authors concluded the produced films showed great promise for use as wound dressing materials for prophylactic or treatment of mucosal and topical infections.
The role of hydrogen bonds in the mesomorphic behaviour of supramolecular assemblies organized in dendritic architectures
Published in Liquid Crystals Reviews, 2019
Michael Arkas, I. Kitsou, A. Gkouma, M. Papageorgiou
In an attempt to synthesize dendronized p-conjugated poly(isocyanide)s, Tian and his group [129], observed that their isocyanide dendron monomers (Figure 13) did not exhibit liquid crystalline phases whereas respective hydrated precursors bearing formamido (HCONH-) moieties (Figure 14) formed columnar and cubic phases due to dimerization and polymerization via intermolecular hydrogen bonding as confirmed by IR spectroscopy (Figure 15). This is a rare and exceptionally interesting example of a supramolecular liquid crystalline dendronized polymer formed through hydrogen bonds that owes its mesomorphic properties exclusively to them.