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Terpenoids in Treatment of Neurodegenerative Disease
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Caryophyllene, or β-caryophyllene (BCP), is a sesquiterpene, made of three isoprene units and found in many different edible plants. Spices like black pepper, cloves and cinnamon, as well as herbs like oregano, basil, hops and rosemary, are known to exhibit high concentrations of BCP species.
Varronia verbenacea and Achyrocline satureioides essential oils in granules and microparticles: Stability and in vitro release studies
Published in Drying Technology, 2021
J. C. K. Monteiro Filho, R. A. F. Rodrigues
Among these three marker molecules, fortunately, α-pinene presents the lowest biological efficacy. According to Paula-Freire et al.[17] and Medeiros et al.[18] trans-caryophyllene is intimately related to the anti-inflammatory and antinociceptive effects of these essential oils, as well as the anti-inflammatory effect of α-humulene (already identified as being responsible for the biological action in a commercial product—Acheflan®). In addition to these effects, both molecules act together to exhibit anticancer activity, as reported by El Hadri et al.,[20] indicating their synergistic action. Because of these compounds, the loss of α-pinene could mean not only that the essential oil would remain active, but also that the oils obtained at the end could be enriched and less mass would be required to obtain the same effective dosage.
Essential oil composition and biological activities of Aleppo pine (Pinus halepensis Miller) needles collected from different Tunisian regions
Published in International Journal of Environmental Health Research, 2023
Sarra Dakhlaoui, Soumaya Bourgou, Sarra Bachkouel, Rim Ben Mansour, Mariem Ben Jemaa, Slim Jallouli, Wided Megdiche-Ksouri, Kamel Hessini, Kamel Msaada
The antitumoral activity of P. halepensis EO is not well investigated in literature. However, seed extracts were proved to display antiproliferative action against U-87 MG tumoral brain cells and antiangiogenic effect against human myeloma (HL60) and human colon adenocarcinoma (HCT15) (El Omari et al. 2021). Further, our results could be attributed to the presence of caryophyllene identified as a major compound. Indeed, according to Dahham et al. (2015), β-caryophyllene purified from Aquilaria crassna EO demonstrated cytotoxic effect against colon (HT-29 and HCT-116), pancreatic (PANC-1) and breast (MCF-7) cancer cell lines.
Identification and quantification of β-caryophyllene in copaiba oil using Raman spectroscopy
Published in Instrumentation Science & Technology, 2018
José Aparecido Boaroto, Adriana Barrinha Fernandes, Leonardo Marmo Moreira, Landulfo Silveira, Carlos José de Lima
The scientific literature reported the presence of several compounds in copaiba oleoresins (mainly the terpenes), and most of them have shown biologic activities and medicinal properties.[8,9]. Several biologic activities have been attributed to β-caryophyllene, such as insecticidal,[10] antimicrobial,[11] local anesthetic,[12] anticarcinogenic,[13] and anti-inflammatory effects.[14]