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Proteins and proteomics
Published in Firdos Alam Khan, Biotechnology Fundamentals, 2018
QPNC-PAGE, or quantitative preparative native continuous PAGE, is a high-resolution technique applied in biochemistry and bioinorganic chemistry to separate proteins by isoelectric point. This variant of gel electrophoresis is used by biologists to isolate active or native metalloproteins in biological samples and to resolve properly and improperly folded metal cofactor-containing proteins in complex protein mixtures.
Application of Industry 5.0 in the Production of Fine Chemicals and Biopolymers
Published in Pau Loke Show, Kit Wayne Chew, Tau Chuan Ling, The Prospect of Industry 5.0 in Biomanufacturing, 2021
Nurul Natasha binti Azhar, Kai Ling Yu, Tau Chuan Ling, Pau Loke Show
Biochemical engineering is a field that has the discipline of chemical engineering at its core but adopts the concepts of biochemistry, bioorganic and bioinorganic chemistry as well as cell and molecular biology (Clark and Blanch 1997). In layman terms, biochemical engineering uses living organisms, or the chemical products that they produce such as enzymes, to develop new processes that produce chemical or biological materials (Clark and Blanch 1997). Early applications of biochemical engineering began when humans used yeast and fungi to make bread, wine, cheese and beer (Clark and Blanch 1997). Recent decades show that biochemical engineering has progressed to create biodegradable plastic containers from microbes (Philbrook, Alissandratos, and Easton 2013) as well as antibiotics (Najafpour 2015) and electrodes from fungi (Ludwig et al. 2013). One of the key environmental advantages of applying biochemical engineering concepts in a process is the fact that the processes are able to produce complex polymers and chemical compounds that cannot be achieved through conventional chemical production processes while having mild operating conditions and minimum waste generated (Takors 2020). In doing so, the environmental impacts related to the waste management of the process can be significantly reduced (Takors 2020). The Fifth Industrial Revolution presents the concepts of mass personalization and the collaboration between man and artificial intelligence, which can present an opportunity for the field of biochemical engineering to take part in the new manufacturing revolution. Biochemical engineering can partake in IR 5.0 through the advances and the applications of different fields such as white biotechnology, synthetic biology and evolutionary algorithms in the production process to create processes with higher flexibility at a lower environmental and economic cost. The concepts developed from the combination of the abovementioned fields with biochemical engineering can then be applied in the production processes of various manufactured goods including fine chemicals and biopolymers.
A review on the biomedical efficacy of transition metal triazole compounds
Published in Journal of Coordination Chemistry, 2022
Sajjad Hussain Sumrra, Wardha Zafar, Muhammad Imran, Zahid Hussain Chohan
The compounds were also examined by enzyme inhibition bioassay against butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). The cholinesterase inhibitory activity of the compounds has shown relatively greater activity for BChE in contrast to AChE enzyme. The antioxidant profile of these synthesized triazole compounds was explored by using the DPPH method, total phenolic content and iron reducing power assay. Complexes showed comparable results of antibacterial, antifungal and antioxidant activity with that of standard drugs but 3d-metal chelates exhibited higher biological activity as compared to their respective ligands. These investigations will help to develop new metal based drugs for the treatment of microbial infectious diseases. Due to antimicrobial abilities, the synthesized compounds could help the pharmaceutical industry to reduce growth of pathogens. These promising results are supportive for different biological applications. Advancements in bioinorganic chemistry are required to refine the design of new and more effective biological compounds, and investigate their mechanism of action to design and develop new types of drugs for the pharmaceutical industry.
Kinetics and mechanism for ligand substitution reactions of some square-planar platinum(II) complexes: Stability and reactivity correlations
Published in Inorganic and Nano-Metal Chemistry, 2018
Debabrata Nandi, Parnajyoti Karmakar, Sumon Ray, Animesh Chattopadhyay, Roshni Sarkar(Sain), Alak K. Ghosh
Transition metals and their reactions are of general importance in the treatment of many diseases (cancer, arthritis, diabetes, Alzheimer's, etc.), but with little understanding of their mechanism of action in biological systems.[1,2] Biochemical studies have not clearly established the molecular basis for the activity and mechanism of action. The growing field of bioinorganic chemistry is presently dealing with the clarification of the mechanisms of action of metal complexes in biological systems.[3] Research in the area of the application of metal complexes in medicine began with the discovery of the anti-tumour properties of cisplatin.[4] Among the large number of synthesized compounds, only a few of them have entered medicinal use and most are still under preclinical investigations.[5,6] Some of the platinum complexes that are used in cancer treatment or that have entered clinical trials are depicted in Figure 1.
Synthesis, characterization, HSA interaction, and antibacterial activity of a new water-soluble Pt(II) complex containing the drug cephalexin
Published in Journal of Coordination Chemistry, 2018
Nahid Shahabadi, Shokoufeh Hashempour, Avat (Arman) Taherpour, Fariba Mohsenzadeh
Bioinorganic chemistry is a field that examines the role of metal complexes in biological systems. It has opened up a new horizon for scientific research in coordination compounds. Due to the outbreak of infectious diseases caused by various pathogenic bacteria and the development of antibiotic resistance, new antibacterial agents are needed [1].