4-aminobiphenyl

4-aminobiphenyl

4-aminobiphenyl is a chemical compound with the molecular formula C^H^N and a molecular weight of 169.24. It is known to be carcinogenic and has been linked to bladder cancer in humans, particularly in those who have been occupationally exposed to commercial 4-aminobiphenyl. Exposure to this compound is believed to initiate bladder cancer.From: Regulatory Chemicals Handbook [2019], Chemical Exposure and Toxic Responses [2020], Overview of biological mechanisms of human carcinogens [2019]

Chemical Exposure and Cancer

View Chapter

Purchase Book

Published in Stephen K. Hall, Joana Chakraborty, Randall J. Ruch, Chemical Exposure and Toxic Responses, 2020

Gary D. Stoner

This aromatic amine was formerly used as a rubber antioxidant and dye intermediate. The evidence for carcinogenicity of 4-aminobiphenyl to humans is confined to one series of workers exposed occupationally to commercial 4-aminobiphenyl; they showed a high incidence of bladder cancer.

Overview of biological mechanisms of human carcinogens

View Article

Journal Information

Published in Journal of Toxicology and Environmental Health, Part B, 2019

Nicholas Birkett, Mustafa Al-Zoughool, Michael Bird, Robert A. Baan, Jan Zielinski, Daniel Krewski

4-Aminobiphenyl was used mainly in industrial settings as an antioxidant in rubber, as a dye intermediate, and in the detection of sulfates. This compound use in industry was phased out in the mid-1950s. Non-industrial exposure occurs primarily through smoking. Exposure to 4-aminobiphenyl initiates bladder cancer.

Explore chapters and articles related to this topic

Chemical Exposure and Cancer

Overview of biological mechanisms of human carcinogens