China
Africa
Explore chapters and articles related to this topic
Medical Applications for 3D Printing
Published in Yoseph Bar-Cohen, Advances in Manufacturing and Processing of Materials and Structures, 2018
David K. Mills, Karthik Tappa, Uday Jammalamadaka, Patrick A.S. Mills, Jonathan S. Alexander, Jeffery A. Weisman
Among the biodegradable synthetic polymers that offer significant potential for customization is PCL, a semicrystalline polymer that exhibits good mechanical properties, has a low melting point (55°C), and is both biocompatible and biodegradable (Hollister, 2005; Schantz et al., 2005; Wang et al., 2007). It is formed by the ring opening polymerization process of ε-caprolactone. In the body, PCL degrades in two phases. It first undergoes hydrolysis of ester bonds and forms fragments of caprolactone oligomers. These oligomers are then engulfed by macrophages, and they undergo degradation inside phagosomes by lysozyme enzymes (Barrows, 1986). Since this polymer exhibits low mechanical strength, its use in implant technology is limited to non-load-bearing regions exclusively.
A systematic review of biodegradable materials in the textile and apparel industry
Published in The Journal of The Textile Institute, 2023
HuiYing Bao, Yan Hong, Tao Yan, Xiufen Xie, Xianyi Zeng
Polycaprolactone (PCL) is a linear polymer made of monomer ε-caprolactone (ε-CL) by ring-opening polymerization under the action of catalyst. It has a regular molecular weight and is easily crystallized. It is a biodegradable semi-crystalline polyester. In terms of performance, the glass transition temperature of PHA is about −60 °C. The melting point is between 59 ∼ 64 °C. The thermal decomposition temperature is about 250 °C. It has low melting point, good flexibility and toughness. It is convenient for processing and molding, and can be injection molding, extrusion, etc. PCL fiber degradation property is good, not only for home composting, but also for seawater degradation environment. It is the most promising bio-polyester at present. It can partially replace PLA for production use.
Fabrication of polymer-based self-assembly nanocarriers loaded with a crizotinib and gemcitabine: potential therapeutics for the treatment of endometrial cancer
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Jiaolin Yang, Hongrui Guo, Jing Lei, Sanyuan Zhang, Shaoguo Zhang, Jirong Bai, Sufen Li
Tri-block copolymer poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, MW = 3700) was fabricated by ring-opening polymerization methods according to the previously reported protocol [38–41]. 30 mg CRZ and 30 mg GEM were dissolved first in 10 ml methanol to fabricate the CRZ@GEM-NPs. Next, the weighing and dissolving in 4 ml dichloromethane (DCM) of 24 mg tri-block copolymer. The two drugs and polymer systems were dissolved entirely in DCM solution and had a clear yellow color after the two solutions had been combined uniformly. These two solutions were then integrated and then evaporated to remove a rotary evaporator using the organic solvent (35 °C). The film was washed with deionized water warmed at 60 °C. After this, a 0.22 μm (Millipore, MA, USA) nanoparticles solution has been removed from the unencapsulated CRZ and GEM filter, and a cleared solution has been acquired. Lastly, the filtrate was freeze-dried and achieved the drug delivery system of CRZ@CUR-NPs samples for further in vitro and in vivo use.
Biopolymer composites: a review
Published in International Journal of Biobased Plastics, 2021
Basheer Aaliya, Kappat Valiyapeediyekkal Sunooj, Maximilian Lackner
The biodegradable polymers derived from petrochemical resources are polybutylene succinate (PBS), poly(butylene adipate-co-terephthalate) (PBAT), polyvinyl alcohol (PVA), polyglycolic acid (PGA), and polycaprolactone (PCL). PBS are easily processed semi-crystalline thermoplastic polyesters with acceptable thermo-mechanical properties comparable to PP [77], and thus widely used in bottles and films production. PBS is made up of 1,4-butanediol and succinic acid from renewable resources [14]. The tensile strength (30–35 MPa) of PBS is similar to that of PP and the Young’s modulus (300–800 MPa) is between low-density polyethylene (LDPE) and high-density polyethylene (HDPE) [74]. PBAT belonging to the family of aliphatic-aromatic copolyesters is a biodegradable copolymer of terephthalate and butylene adipate produced by melt polycondensation process [74]. PVA is a hydrophilic semi-crystalline biopolymer exhibiting good mechanical strength and biocompatibility. The properties of PVA make it a promising material for biological as well as industrial applications [63]. PCL is a hydrophobic semi-crystalline aliphatic polyester prepared by ring-opening polymerization of ε-caprolactone. PCL is tough and ductile (elongation at break ~600–800%) and has low glass transition temperature (~ −60°C) and melting temperature (~60°C) [74]. It is mainly used in packaging and biomedical applications.